IMAGING BRAIN MATURATION AND NEUROBEHAVIORAL CORRELATES

大脑成熟成像和神经行为相关性

基本信息

项目摘要

The primary objectives of this proposal are to localized and stage structural maturational brain changes between childhood and adolescence using structural magnetic resonance imaging (sMRI), and to relate these brain changes to improving cognitive abilities assessed with cognitive psychological tests of learning and memory and functioning MRI (fMRI). Neurodevelopment in normal children and adolescents is not yet well understood, but the few studies in the literature that have focused on this topic have shown regionally specific age-related changes in brain morphology. These maturational changes are characterized by great variability between individuals, even within narrow chronological age ranges. Such variability is also found in normative studies of improving cognitive abilities, and correlations have been found between cognitive measures and some brain measures. Notably, these relationships do not tend to be mediated by age, suggesting that maturational factors that are not well indexed by chronological age are involved with the plasticity in brain structure and its neurobehavioral correlates. The increased understanding of normal brain development obtained through this proposed program of research will be useful in scientific endeavors to understand aberrant brain maturation and cognitive impairments in children with various neurodevelopmental disorders, understand aberrant brain maturation and cognitive impairments in children with various neurodevelopmental disorders. This proposal details a plan for didactic study, enabling the candidate to acquire new skills in acquisition and analysis of sMRI and fMRI data, with supervised research to address the following specific aims: (1) To analyze existing high resolution imaging data from 300 normal children and adolescents by adapting measurement tools that will provide localized information about structural change throughout development. (2) To categorize individuals based on sMRI data in such a way to enable reasonable comparisons across developmental stages. It is hypothesized that chronological age will only roughly correlate with groups of subjects that are categorized by patterns of changing brain structure. (3) To investigate neurobehavioral correlates of brain maturation in a small prospective study using sMRI, and modern cognitive psychological tests for detailed assessment of learning and memory abilities. (4) To assess neurobehavioral assessment. It is hypothesized that dissociative brain regions will be involved in distinct cognitive functions (e.g., verbal memory vs. spatial memory), and similar brain regions will be implicated in the fMRI studies of memory, and the sMRI/memory correlation studies.
该提案的主要目标是使用结构磁共振成像(sMRI)定位和分期儿童期和青春期之间的结构成熟大脑变化,并将这些大脑变化与学习和记忆的认知心理测试和功能MRI(fMRI)评估的认知能力改善相关联。正常儿童和青少年的神经发育尚未得到很好的理解,但文献中关注这一主题的少数研究表明,大脑形态学存在区域特异性年龄相关变化。这些成熟变化的特点是个体之间的差异很大,即使在狭窄的实足年龄范围内。在提高认知能力的规范性研究中也发现了这种变异性,并且在认知测量和一些大脑测量之间发现了相关性。值得注意的是,这些关系不倾向于由年龄介导,这表明,成熟的因素,没有很好地索引的实足年龄参与大脑结构的可塑性及其神经行为相关。通过这项拟议的研究计划获得的正常大脑发育的理解将有助于科学工作,以了解各种神经发育障碍儿童的异常大脑成熟和认知障碍,了解各种神经发育障碍儿童的异常大脑成熟和认知障碍。本提案详细说明了教学研究计划,使候选人能够获得获取和分析sMRI和fMRI数据的新技能,并进行监督研究,以解决以下具体目标:(1)通过调整测量工具,分析300名正常儿童和青少年的现有高分辨率成像数据,这些工具将提供有关整个发育过程中结构变化的本地化信息。(2)根据sMRI数据对个体进行分类,以便在发育阶段进行合理的比较。据推测,实足年龄只会粗略地与根据大脑结构变化模式分类的受试者群体相关。(3)在一项小型前瞻性研究中,使用sMRI和现代认知心理学测试详细评估学习和记忆能力,研究大脑成熟的神经行为相关性。(4)评估神经行为评估。假设分离性脑区将参与不同的认知功能(例如,言语记忆与空间记忆),以及类似的脑区域将涉及记忆的fMRI研究和sMRI/记忆相关性研究。

项目成果

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ELIZABETH R SOWELL其他文献

ELIZABETH R SOWELL的其他文献

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{{ truncateString('ELIZABETH R SOWELL', 18)}}的其他基金

Prenatal and Early Postnatal Lead Exposure on Childhood and Adolescent Brain, Cognitive and Behavioral Development
产前和产后早期铅暴露对儿童和青少年大脑、认知和行为发育的影响
  • 批准号:
    10450156
  • 财政年份:
    2020
  • 资助金额:
    $ 15.12万
  • 项目类别:
Prenatal and Early Postnatal Lead Exposure on Childhood and Adolescent Brain, Cognitive and Behavioral Development
产前和产后早期铅暴露对儿童和青少年大脑、认知和行为发育的影响
  • 批准号:
    10653054
  • 财政年份:
    2020
  • 资助金额:
    $ 15.12万
  • 项目类别:
Prenatal and Early Postnatal Lead Exposure on Childhood and Adolescent Brain, Cognitive and Behavioral Development
产前和产后早期铅暴露对儿童和青少年大脑、认知和行为发育的影响
  • 批准号:
    10240486
  • 财政年份:
    2020
  • 资助金额:
    $ 15.12万
  • 项目类别:
Prenatal and Early Postnatal Lead Exposure on Childhood and Adolescent Brain, Cognitive and Behavioral Development
产前和产后早期铅暴露对儿童和青少年大脑、认知和行为发育的影响
  • 批准号:
    10379790
  • 财政年份:
    2020
  • 资助金额:
    $ 15.12万
  • 项目类别:
Brain and Cognitive Development in the PASS Cohort: The Impact of PrenatalAlcohol Exposure
PASS 队列中的大脑和认知发展:产前酒精暴露的影响
  • 批准号:
    10737503
  • 财政年份:
    2017
  • 资助金额:
    $ 15.12万
  • 项目类别:
Brain and Cognitive Development in the PASS Cohort: The Impact of Prenatal Alcohol Exposure
PASS 队列中的大脑和认知发展:产前酒精暴露的影响
  • 批准号:
    10172802
  • 财政年份:
    2017
  • 资助金额:
    $ 15.12万
  • 项目类别:
Brain and Cognitive Development in the PASS Cohort: The Impact of Prenatal Alcohol Exposure
PASS 队列中的大脑和认知发展:产前酒精暴露的影响
  • 批准号:
    9285211
  • 财政年份:
    2017
  • 资助金额:
    $ 15.12万
  • 项目类别:
Imaging Brain, Neurocognitive and Pubertal Maturation During Adolescence
青春期大脑、神经认知和青春期成熟的成像
  • 批准号:
    8511826
  • 财政年份:
    2010
  • 资助金额:
    $ 15.12万
  • 项目类别:
Imaging Brain, Neurocognitive and Pubertal Maturation During Adolescence
青春期大脑、神经认知和青春期成熟的成像
  • 批准号:
    8316333
  • 财政年份:
    2010
  • 资助金额:
    $ 15.12万
  • 项目类别:
Imaging Brain, Neurocognitive and Pubertal Maturation During Adolescence
青春期大脑、神经认知和青春期成熟的成像
  • 批准号:
    8501845
  • 财政年份:
    2010
  • 资助金额:
    $ 15.12万
  • 项目类别:
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