Longitudinal Mapping of Maturational Change in Brain Function-Structure Relations

脑功能-结构关系成熟变化的纵向绘图

• 批准号: 7995992
• 负责人: ELIZABETH R SOWELL
• 金额: $ 58.27万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-05 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7995992
• 关键词: Accounting; Address; Adolescence; Adult; Affect; Age; Area; Attention deficit hyperactivity disorder; Autistic Disorder; Automobile Driving; Behavioral; Bilateral; Biological; Biological Neural Networks; Biomedical Computing; Brain; Brain region; Broca' s area; Cell physiology; Child; Childhood; Cognitive; Competence; Complex; Computational Biology; Coupled; Cross-Sectional Studies; Data; Development; Dorsal; Dyslexia; Environment; Etiology; Evaluation; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Future; Goals; Homologous Gene; Human; Hybrids; Image; Impairment; Individual; Inferior; Inferior frontal gyrus; Intervention; Laboratories; Language; Language Development; Lead; Left; Life; Linguistics; Literature; Longevity; Longitudinal Studies; Magnetic Resonance Imaging; Maps; Medical Research; Nature; Neurocognitive; Orthography; Parietal; Pathway interactions; Pattern; Performance; Pilot Projects; Population; Principal Investigator; Process; Protocols documentation; Psychological reinforcement; Qualifying; Reading; Recording of previous events; Recruitment Activity; Relative (related person); Research; Role; Sampling; Signal Transduction; Social Interaction; Solutions; Specificity; Structure; Structure-Activity Relationship; Study Subject; Synapses; System; Target Populations; Task Performances; Testing; Thick; Time; United States National Institutes of Health; Wernicke Area; age effect; age related; base; brain behavior; cognitive change; cognitive function; density; design; developmental disease; executive function; frontal lobe; frontal lobe function; gray matter; insight; interest; language processing; morphometry; myelination; neurocognitive test; neurodevelopment; neuroimaging; neuropsychological; programs; relating to nervous system; response; skills; stem; syntax

DESCRIPTION (provided by applicant): The overarching goal of the proposed studies is to longitudinally investigate the functional and behavioral significance of structural change in the form of gray matter thickness increases recently observed in classical brain language regions during the process of normal development. We will also assess functional activation in non-language frontal lobe regions (where cortical thinning has been observed) to evaluate the cognitive/functional significance and regional specificity of dynamic changes observed in our earlier studies of structural brain maturation. By delineating the relationship among language developments, executive function development, brain function, and brain structure, this study will bridge the informational gap on the neural basis of language and frontal function in the normally developing brain. We will use functional and structural magnetic resonance imaging and detailed neurocognitive assessments to assess the following specific aims: 1) To quantify change in functional and structural signal within children studied longitudinally; 2) To investigate whether change in functional signal across time is related to change in the underlying brain structure; and 3) To relate behavioral language and frontal lobe functioning change to changes in brain structure and function. We propose to study children between the ages of 5 and 9 years (with 2 years between repeat evaluations) when so many language and frontal lobe functions are rapidly changing as are brain structures related to these cognitive domains. The proposed longitudinal project will highlight how an integrated approach relating behavioral, functional, and structural data might yield important new insights on the complex nature of brain- behavior interactions. To our knowledge, this will be the first study to undertake such challenges by using both functional and structural MRI to examine, longitudinally, the neural networks associated with language processing (i.e., reading), within the same individuals, and to relate the normal developmental changes in the neural networks subserving language processing (as observed with fMRI) to age-related changes in brain morphometry (as assessed by structural MRI). Similar evaluations will be made with tests of frontal lobe functioning allowing assessment of relationships between patterns of change in language and non-language brain regions. The data gathered from the proposed longitudinal research program should enable us to more fully elucidate the neural developments associated with the emergence of mature linguistic and frontal lobe competence in normally developing children. Furthermore, these developmental findings will provide normative data for evaluating the patterns of brain dysfunction associated with the linguistic, communicative, and frontal lobe impairments observed in a variety of developmental disorders (e.g., dyslexia, autism, ADHD).

DESCRIPTION (provided by applicant): The overarching goal of the proposed studies is to longitudinally investigate the functional and behavioral significance of structural change in the form of gray matter thickness increases recently observed in classical brain language regions during the process of normal development. We will also assess functional activation in non-language frontal lobe regions (where cortical thinning has been observed) to evaluate the cognitive/functional significance and regional specificity of dynamic changes observed in our earlier studies of structural brain maturation. By delineating the relationship among language developments, executive function development, brain function, and brain structure, this study will bridge the informational gap on the neural basis of language and frontal function in the normally developing brain. We will use functional and structural magnetic resonance imaging and detailed neurocognitive assessments to assess the following specific aims: 1) To quantify change in functional and structural signal within children studied longitudinally; 2) To investigate whether change in functional signal across time is related to change in the underlying brain structure; and 3) To relate behavioral language and frontal lobe functioning change to changes in brain structure and function. We propose to study children between the ages of 5 and 9 years (with 2 years between repeat evaluations) when so many language and frontal lobe functions are rapidly changing as are brain structures related to these cognitive domains. The proposed longitudinal project will highlight how an integrated approach relating behavioral, functional, and structural data might yield important new insights on the complex nature of brain- behavior interactions. To our knowledge, this will be the first study to undertake such challenges by using both functional and structural MRI to examine, longitudinally, the neural networks associated with language processing (i.e., reading), within the same individuals, and to relate the normal developmental changes in the neural networks subserving language processing (as observed with fMRI) to age-related changes in brain morphometry (as assessed by structural MRI). Similar evaluations will be made with tests of frontal lobe functioning allowing assessment of relationships between patterns of change in language and non-language brain regions. The data gathered from the proposed longitudinal research program should enable us to more fully elucidate the neural developments associated with the emergence of mature linguistic and frontal lobe competence in normally developing children. Furthermore, these developmental findings will provide normative data for evaluating the patterns of brain dysfunction associated with the linguistic, communicative, and frontal lobe impairments observed in a variety of developmental disorders (e.g., dyslexia, autism, ADHD).