CORE--DATA MANAGEMENT AND COMPUTING

核心单元B的目标是提供以下数据库管理 西南地区实验室产生的基因和表型数据 与此相关的遗传学和家族学基础系 数据。核心B还负责数据质量控制，支持 应用软件，提供网络和系统管理 此计划项目使用的计算机，并保护机密性 和项目数据的安全性。 该核心单位在拟议赠款期间的具体目标是 (1)管理计算机数据的获取和控制 计划项目，并维护实验室数据采集软件； (2)保存一份血液和组织样本的库存 研究过程；(3)管理实验室间的文件传输；(4) 处理实验室数据并维护用于以下目的的软件 处理；(5)建立和维护计算机化家谱 数据；(6)控制收集数据的质量；(7)对原始数据进行处理 将数据转换成适合进行基因分析的形式；(8)管理 中不符合孟德尔期望的标记的分辨率 我们的系谱；(9)管理标记上IBD矩阵的计算 (10)进一步开发和改进软件 用于本计划项目；和(11)承担系统管理 维护我们的计算机系统及其通信所需的任务 网络作为ITS应用于本计划项目，并保护 在本研究过程中收集的数据的完整性。

The objectives of Core Unit B are to provide database management for genotypic and phenotypic data generated in laboratories at the Southwest Foundation Department of Genetics and for pedigrees associated with these data. Core B also is responsible for data quality control, supports applications software, provides network and systems management for computers used by this Program Project, and protects the confidentiality and security of project data. Specific aims of this core unit during the proposed grant period are (1) to manage acquisition and control of computerized data used in this Program Project, and to maintain laboratory data acquisition software; (2) to maintain an inventory of blood and tissue samples collected in the course of the research; (3) to manage inter-laboratory file transfer; (4) to process laboratory data and to maintain the software used for processing; (5) to construct and maintain computerized pedigrees of family data; (6) to control the quality of the data collected; (7) to process raw data into forms suitable for genetic analysis; (8) to manage the resolution of markers that fail to conform to Mendelian expectations in our pedigrees; (9) to manage the computation of IBD matrices on marker loci as they are developed; (10) to further develop and enhance software used in this Program Project; and (11) to undertake systems management tasks as needed to maintain our computer system and its communications network as its is applied to this Program Project, and to protect the integrity of data collected during the course of this research.