CORE--DATA MANAGEMENT AND COMPUTING

核心单元B的目标是提供数据库管理， 西南地区实验室产生的基因型和表型数据 基金会遗传学系和与这些相关的谱系 数据核心B还负责数据质量控制，支持 应用软件，提供网络和系统管理， 本计划项目使用的计算机，并保护机密性 项目数据的安全。 在建议的资助期内，这个核心单位的具体目标是 (1)管理在此过程中使用的计算机化数据的获取和控制， 计划项目，并维护实验室数据采集软件; (2)保存在医院采集的血液和组织样本的清单， （3）管理实验室间的文件传输;（4） 处理实验室数据并维护用于 （5）建立和维护家系的计算机化系谱 （6）控制收集数据的质量;（7）处理原始数据; 数据转换成适合遗传分析的形式;（8）管理 不符合孟德尔期望的标记的分辨率， 我们的谱系;（9）管理IBD矩阵的计算标记 （10）进一步开发和增强软件 （11）进行系统管理; 维护我们的计算机系统及其通信所需的任务 网络，因为它适用于本计划项目，并保护 本研究过程中收集的数据的完整性。

The objectives of Core Unit B are to provide database management for genotypic and phenotypic data generated in laboratories at the Southwest Foundation Department of Genetics and for pedigrees associated with these data. Core B also is responsible for data quality control, supports applications software, provides network and systems management for computers used by this Program Project, and protects the confidentiality and security of project data. Specific aims of this core unit during the proposed grant period are (1) to manage acquisition and control of computerized data used in this Program Project, and to maintain laboratory data acquisition software; (2) to maintain an inventory of blood and tissue samples collected in the course of the research; (3) to manage inter-laboratory file transfer; (4) to process laboratory data and to maintain the software used for processing; (5) to construct and maintain computerized pedigrees of family data; (6) to control the quality of the data collected; (7) to process raw data into forms suitable for genetic analysis; (8) to manage the resolution of markers that fail to conform to Mendelian expectations in our pedigrees; (9) to manage the computation of IBD matrices on marker loci as they are developed; (10) to further develop and enhance software used in this Program Project; and (11) to undertake systems management tasks as needed to maintain our computer system and its communications network as its is applied to this Program Project, and to protect the integrity of data collected during the course of this research.