CORE--COMPUTING AND DATA MANAGEMENT

描述(由申请人提供) 核心B的目标是为以下项目提供数据库管理 西南地区实验室产生的基因/表型数据 遗传学基础系，用于临床和访谈数据生成 根据核心A和基于这些数据的家系。核心B还规定 数据质量控制，支持应用软件，提供网络和 西南地区本项目所用计算机的系统管理 基础，并保护项目数据的机密性和安全性。 在拟议的赠款期间，该核心的具体目标是1个要管理的 本程序使用的计算机化数据的获取、录入和控制 项目，并维护实验室数据采集软件；2维护 在调查过程中收集的血液样本的计算机化清单 研究；3个实验室间和4个机构间数据和档案管理 移交；5处理实验室数据并维护用于以下目的的软件 处理；6建立和维护计算机化的家谱数据； 7控制收集数据的质量；8将原始数据转化为 适用于基因分析的表格；9保护数据的机密性； 10进一步开发和增强本计划项目中使用的软件，如 需要；11根据需要承担系统编程任务，以维持 计算机系统及其通信网络；12为数据提供备份 和系统文件；以及13以保护 此计划项目中使用的计算机。

DESCRIPTION (provided by applicant) Objectives of Core B are to provide database management for genotypic/phenotypic data generated in laboratories at the Southwest Foundation Department of Genetics, for clinical and interview data generated by Core A, and for pedigrees based on these data. Core B also provides for data quality control, supports applications software, provides network and systems management for computers used by this Program Project at the Southwest Foundation, and protects the confidentiality and security of project data. Specific aims of this core during the proposed grant period are 1 to manage acquisition, entry, and control of computerized date used in this Program Project, and to maintain laboratory data acquisition software; 2 to maintain a computerized inventory of blood samples collected in the course of the research; 3 to manage inter-laboratory and 4 inter-institutional data and file transfer; 5 to process laboratory data and to maintain the software used for processing; 6 to construct and maintain computerized pedigrees of family data; 7 to control the quality of the data collected; 8 to transform raw data into forms suitable for genetic analysis; 9 to protect the confidentiality of data; 10 to further develop and enhance software used in this Program Project as needed; 11 to undertake systems programming tasks as needed to maintain the computer system and its communications network; 12 to provide backup for data and systems files; and 13 to protect the integrity and the security of the computers used in this Program Project.