GENETIC & DEMOGRAPHIC MANAGEMENT OF BREEDING COLONIES

该项目的目标是确定 母乳喂养与胆汁酸代谢的营养程序比较。 配方奶喂养及其与甲状腺激素水平的关系。这个 具体目的是检验以下假设：1)母乳喂养与 配方奶喂养对成人胆汁酸代谢的不同影响 和2)甲状腺激素(T4)的营养规划和 三碘甲腺原氨酸(T_3)浓度调节 胆汁酸形成的变量。我们的初选结果 研究和其他调查小组的研究表明 母乳喂养与配方奶喂养的方案不同 脂蛋白浓度、胆汁酸合成与动脉粥样硬化 狒狒和人类。拟议的研究将确定具体的 胆汁酸代谢中受早期营养控制的基因 以及甲状腺激素的潜在作用。基因的表达可以 受到多种控制措施的影响，包括DNA甲基化， 转录因子，或基因结构。拟议的研究将 确定胆汁酸代谢中的特定基因 早期营养与甲状腺的潜在作用 荷尔蒙。基因的表达可能会受到多个对照的影响， 包括DNA甲基化、转录因子或基因结构。 在这项研究中，识别受早期饮食影响的基因将 为今后研究黄曲霉毒素的分子机制奠定了基础 营养节目。

The goal of this project is to determine the mechanism of nutritional programming of bile acid metabolism by breast-feeding vs. formula-feeding and the relationship to thyroid hormone levels. The specific aims are to test the hypotheses that: 1) breast-feeding vs. formula-feeding differentially programs bile acid metabolism in adult baboons; and 2) nutritional programming of thyroxine (T4) and trilodothyronine (T3) concentrations mediates the programming of variables of bile acid formation. Results from our preliminary studies and from those of other groups of investigators have shown that breast-feeding vs. formula-feeding differentially programs lipoprotein concentrations, bile acid synthesis, and atherogenesis in baboons and humans. The proposed studies will identify the specific genes in bile acid metabolism that are programmed by early nutrition and the potential role of thyroid hormones. Expression of genes may be affected by multiple controls, including DNA methylation, transcription factors, or gene structure. The proposed studies will identify the specific genes in bile acid metabolism that are programmed by early nutrition and the potential role of thyroid hormones. Expression of genes may be affected by multiple controls, including DNA methylation, transcription factors, or gene structure. Identification of the genes affected by early diet in this study will provide a basis for future studies on the molecular mechanisms of nutritional programming.