Global microbiome analysis of the desert adapted Acomys russatus and Acomys cahirinus.

我们正在寻找一位具有计算生物学背景的有创造力和上进心的博士候选人加入一个动态的、多学科的研究团队，研究环境和微生物区系及其相互作用。这个职位在厄勒姆研究所的大卫·蒂伯特博士实验室内，与新成立的Quadram研究所的林赛·霍尔博士的实验室密切合作。尽管许多研究集中在饮食和遗传背景对哺乳动物肠道微生物群组成的影响上，但目前对环境对野生哺乳动物的作用知之甚少。环境可以通过食物的可获得性来影响饮食，进而影响肠道微生物的组成。这个博士生的目标是研究和理解肠道微生物区系功能和宿主环境之间的关系，通过对沙漠适应和非适应的Acomys物种的元基因组进行分析来研究和理解肠道微生物区系功能和宿主环境之间的关系，通过分析沙漠适应和非适应的Acomys物种的元基因组来揭示环境造成的元基因组变异。

We are looking for a creative and motivated PhD candidate with a background in computational biology to join a dynamic, multi-disciplinary research team investigating the environment and microbiota and interactions. This position is within Dr David Thybert lab at the Earlham institute with a close collaboration with Dr Lindsay Hall's lab at the newly formed Quadram Institute.Although many studies have focused on the effect that diet and genetic backgrounds have on the gut microbiome composition in mammals, very little is currently known on what role the environment has on wild mammals. The environment could influence both diet via food availability and in turn the gut microbe composition.The goal of this PhD studentship is to study and understand the relationship between gut microbiota function and host environment through a mixture of `dry' (bioinformatics) and `wet' (lab-based) approaches using analysis of metagenomes from desert adapted and non-adapted Acomys species to uncover the metagenome variability due to the environment.