TISSUE PROCUREMENT CORE FACILITY AT JOSEPHINE FORD CANCE

约瑟芬福特坎斯的组织采购核心设施

• 批准号: 6633839
• 负责人: RICHARD ZARBO
• 金额: $ 26.67万
• 依托单位: HENRY FORD HEALTH SYSTEM
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6633839
• 关键词: biomedical facility; cancer information system; cancer registry /resource; human tissue; tissue /organ preservation; tissue resource /registry

DESCRIPTION: (Applicant's Description) The exceptionally high benefit to cost ratio of a centrally operated tissue procurement core facility is well recognized and the need for a core facility at Henry Ford Health System (HFHS) has been acknowledged for some time. On January 15/1999, the Core Facility, a service of the Josephine Ford Cancer Center (JFCC) and housed within the Department of Pathology, became operational. A governing board of 5 members oversees activities of the Facility. We have focused initially on procuring tissue from surgeries performed only at the main hospital to assure the high quality of tissue management. A l2cc blood sample is collected at the time of pre-operative diagnostic blood work. On the day of surgery, an on-call pathologist's assistant collects tissue from operating rooms immediately after completion of the surgery. Each specimen is dissected according to surgical pathology protocol under direct supervision of a pathologist. Normal and malignant sections are separated; tumor samples are further evaluated for necrosis and/or hemorrhage. A separate paraffin block cassette/sample is prepared; blood and tissue specimens are aliquoted into multiple vials and snap frozen at - 80 C. Clinical and demographic data, number of vials/case, reason(s) for not allocating tissue for banking, procurement time, and the availability of matched blood samples are entered into appropriate databases. In the first 6 months, we collected a total of 347 specimens, 39% from African-American and 55% from Caucasian patients. The distribution of tissue by sites includes 17% prostate, 14% colon, 11% breast, 14% lung, and 38% from other organs. Tumor tissue viability ranged between 90- 100% with diagnostic needs as the main reason for not banking. The mean procurement time was 21.5 minutes (+ 3.19). In this application, we propose to continue and expand the operation the Core Facility with 3 foci. First, to strengthen the existing support system for researchers at JFCC. Second, to bank frozen tumor tissues with matched blood and paraffin embedded samples on a routine basis; and third, to accurately interface pathology, treatment outcome and epidemiologic data while maintaining patients' confidentiality.

描述：（申请人的描述）极高的成本效益 集中运营的组织采购核心设施​​的比例很高 亨利·福特医疗系统 (HFHS) 认识到了对核心设施的需求 已经被承认有一段时间了。 1999 年 1 月 15 日，核心设施 约瑟芬·福特癌症中心 (JFCC) 的服务并位于 病理科开始运作。由 5 名成员组成的管理委员会 监督该设施的活动。 我们最初的重点是从仅在以下地点进行的手术中采购组织 主要医院确保组织管理的高质量。 l2cc 在术前诊断血液工作时采集血样。 手术当天，一名待命的病理学家助理从患者身上收集组织。 手术完成后立即进入手术室。每个标本都是 在直接监督下根据手术病理学协议进行解剖 病理学家。正常切片和恶性切片分开；肿瘤样本是 进一步评估坏死和/或出血。单独的石蜡块 准备盒/样品；将血液和组织样本等分到 多个小瓶并在 - 80°C 下快速冷冻。临床和人口统计数据， 每箱小瓶数量、不分配组织用于银行储存的原因、 输入采购时间以及匹配的血液样本的可用性 进入适当的数据库。前 6 个月，我们总共收集了 347 个 样本中，39% 来自非裔美国人，55% 来自白人患者。这 按部位划分的组织分布包括 17% 前列腺、14% 结肠、11% 乳房、 14% 是肺部，38% 来自其他器官。肿瘤组织活力范围在 90- 100% 诊断需求是不办理银行业务的主要原因。平均值 采购时间为 21.5 分钟（+ 3.19）。 在此应用中，我们建议继续并扩展核心业务 具有 3 个焦点的设施。一是强化现有支撑体系 JFCC 的研究人员。其次，将冷冻肿瘤组织与匹配的血液一起储存 和常规石蜡包埋样品；第三，准确地 结合病理学、治疗结果和流行病学数据，同时 维护患者的隐私。