DENTAL FEAR AND ANTICIPATION OF PAIN: IMAGING THE BRAIN
DENTAL FEAR AND ANTICIPATION OF PAIN: IMAGING THE BRAIN
批准号:
6634699
负责人:
Margaret M Bradley
金额:
$19.6万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-04-15 至 2006-03-31
中文摘要
描述:拟议的实验计划旨在评估
恐惧性的大脑功能,伴随着对痛苦刺激的恐惧预期。其
主要目的是确定活动之间的关系,
大脑结构(由局部血流变化定义),
恐惧唤醒,以及皮层电,内脏和躯体反应,
当期待一个痛苦的刺激时发生。这项研究是由一个
人类情感的动机理论,建立在行为,
心理生理学和神经生理学研究。拟议的研究是
旨在解释神经机制,介导的恐惧疼痛,在正常的
人类,此外,检查可能的个体差异,
男女之间,男女之间,
牙齿恐惧症拟议研究的具体目标是映射神经
在即将到来的痛苦引起的恐惧预期期间大脑的激活
刺激,并将获得的大脑地图与心理生理学
恐惧反应的模式评估三个主要独立变量:
1)预期刺激的类型(电击或无痛
振动触觉); 2)受试者的牙科恐惧水平(低,高);和3)性别
个话题吧这八项研究中的每一项(2个刺激类型x 2个恐惧组x 2个
性别)将在磁共振成像(MRI)背景下进行一次,
评估功能性大脑活动,一旦(与新参与者)在一个
模拟MRI环境以获取自主、躯体和中枢(即,EEG)
预期恐惧的生理指标拟议的研究将解决
关于恐惧的神经和心理生理学组织的问题
与即将到来的疼痛有关,以及个体差异如何在恐惧
和/或性别影响这些反应。此外,拟议的方法是,
适应性强,并可随后用于解决其他方面(感官和
(一)疼痛体验。
英文摘要
DESCRIPTION: The proposed experimental program is designed to assess changes in
brain function that occur with fearful anticipation of a painful stimulus. Its
principal aim is to determine the relationship between activity in specific
brain structures (as defined by changes in regional blood flow), reports of
fear arousal, and the electrocortical, visceral, and somatic responses that
occur when expecting a painful stimulus. This research is driven by a
motivational theory of human emotion that is founded on behavioral,
psychophysiological, and neurophysiological research. The proposed studies are
intended to explicate neural mechanisms that mediate fear of pain in normal
humans, and furthermore, to examine possible individual differences in
anticipation of pain between men and women, and between those who are low or
high in dental fear. The specific aim of the proposed research is to map neural
activation in the brain during fearful anticipation evoked by imminent painful
stimulation, and to relate the obtained brain maps to psychophysiological
patterns of fear reactivity. Three primary independent variables are assessed:
1) The type of anticipated stimulus (electric shock or nonpainful
vibrotactile); 2) Dental fear level of the subject (low, high); and 3) Sex of
the subject. Each of these eight studies (2 stimulus type x 2 fear groups x 2
sex) will be conducted once in the magnetic resonance imaging (MRI) context to
assess functional brain activity, and once (with new participants) in a
simulated MRI context to acquire autonomic, somatic, and central (i.e., EEG)
physiological measures of anticipatory fear. The proposed research will address
questions concerning the neural and psychophysiological organization of fear
associated with imminent pain, as well as how individual differences in fear
and/or sex affect these reactions. The proposed methodology is, furthermore,
adaptable and can be used subsequently to address other facets (sensory and
emotional) of the pain experience.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Developing a novel pupillometric assessment of autonomic function: Testing targeted individual differences in BMI, temperament & aerobic fitness
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批准号:9806928
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项目类别:
-
资助金额:$22.88万
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财政年份:2019
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负责人:Margaret M Bradley
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依托单位:
Project 3: Attention to threat: Motivation and Memory
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批准号:7551764
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项目类别:
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资助金额:$15.44万
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财政年份:2007
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负责人:Margaret M Bradley
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依托单位:
Core 3: Media Core (pg 140)
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批准号:7551769
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项目类别:
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资助金额:$17.0万
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财政年份:2007
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负责人:Margaret M Bradley
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依托单位:
Core 3: Media Core (pg 140)
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批准号:6892568
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项目类别:
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资助金额:$18.93万
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财政年份:2004
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负责人:Margaret M Bradley
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依托单位:
Project 3: Attention to threat: Motivation and Memory (pg 206)
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批准号:6892554
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项目类别:
-
资助金额:$16.93万
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财政年份:2004
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负责人:Margaret M Bradley
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依托单位:
DENTAL FEAR AND ANTICIPATION OF PAIN: IMAGING THE BRAIN
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批准号:6516642
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项目类别:
-
资助金额:$19.62万
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财政年份:2001
-
负责人:Margaret M Bradley
-
依托单位:
DENTAL FEAR AND ANTICIPATION OF PAIN: IMAGING THE BRAIN
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批准号:6866417
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项目类别:
-
资助金额:$19.63万
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财政年份:2001
-
负责人:Margaret M Bradley
-
依托单位:
DENTAL FEAR AND ANTICIPATION OF PAIN: IMAGING THE BRAIN
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批准号:6258077
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项目类别:
-
资助金额:$19.62万
-
财政年份:2001
-
负责人:Margaret M Bradley
-
依托单位:
DENTAL FEAR AND ANTICIPATION OF PAIN: IMAGING THE BRAIN
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批准号:6738100
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项目类别:
-
资助金额:$19.63万
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财政年份:2001
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负责人:Margaret M Bradley
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依托单位:
CORE--MEDIA
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批准号:6347655
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项目类别:
-
资助金额:$10.99万
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财政年份:2000
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负责人:Margaret M Bradley
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依托单位:
Motivated attention--Complexity, novelty, or emotion
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批准号:6347650
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项目类别:
-
资助金额:$10.99万
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财政年份:2000
-
负责人:Margaret M Bradley
-
依托单位:
CORE--MEDIA
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批准号:6204934
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项目类别:
-
资助金额:$10.99万
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财政年份:1999
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负责人:Margaret M Bradley
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依托单位:
PROBING EMOTION THROUGH TIME--AFFECT & RESOURCE ALLOCATION
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批准号:6111716
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项目类别:
-
资助金额:$7.31万
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财政年份:1998
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负责人:Margaret M Bradley
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依托单位:
CORE--MEDIA
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批准号:6111723
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项目类别:
-
资助金额:$7.31万
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财政年份:1998
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负责人:Margaret M Bradley
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依托单位:
PROBING EMOTION THROUGH TIME--AFFECT & RESOURCE ALLOCATION
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批准号:6243293
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项目类别:
-
资助金额:$7.68万
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财政年份:1997
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负责人:Margaret M Bradley
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依托单位:
CORE--MEDIA
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批准号:6243300
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项目类别:
-
资助金额:$7.68万
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财政年份:1997
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负责人:Margaret M Bradley
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依托单位:
Motivated attention--Complexity, novelty, or emotion
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批准号:6259582
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项目类别:
-
资助金额:$10.99万
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财政年份:1994
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负责人:Margaret M Bradley
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依托单位:
IMAGERY AND AFFECT: RESPONSES AS CONTEXT IN MEMORY
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批准号:3052707
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项目类别:
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资助金额:$2.5万
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财政年份:1987
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负责人:Margaret M Bradley
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依托单位:
IMAGERY AND AFFECT: RESPONSES AS CONTEXT IN MEMORY
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批准号:3052706
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项目类别:
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资助金额:$2.0万
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财政年份:1987
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负责人:Margaret M Bradley
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依托单位:
Project 3: Attention to threat: Motivation and Memory
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批准号:7644879
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项目类别:
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资助金额:$13.45万
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财政年份:--
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负责人:Margaret M Bradley
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依托单位: