DENTAL FEAR AND ANTICIPATION OF PAIN: IMAGING THE BRAIN

对牙科的恐惧和对疼痛的预期：大脑成像

• 批准号: 6866417
• 负责人: Margaret M Bradley
• 金额: $ 19.63万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-15 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6866417
• 关键词: brain circulation; brain imaging /visualization /scanning; brain mapping; clinical research; fear; gender difference; human subject; magnetic resonance imaging; oral facial pain; psychophysiology

DESCRIPTION: The proposed experimental program is designed to assess changes in brain function that occur with fearful anticipation of a painful stimulus. Its principal aim is to determine the relationship between activity in specific brain structures (as defined by changes in regional blood flow), reports of fear arousal, and the electrocortical, visceral, and somatic responses that occur when expecting a painful stimulus. This research is driven by a motivational theory of human emotion that is founded on behavioral, psychophysiological, and neurophysiological research. The proposed studies are intended to explicate neural mechanisms that mediate fear of pain in normal humans, and furthermore, to examine possible individual differences in anticipation of pain between men and women, and between those who are low or high in dental fear. The specific aim of the proposed research is to map neural activation in the brain during fearful anticipation evoked by imminent painful stimulation, and to relate the obtained brain maps to psychophysiological patterns of fear reactivity. Three primary independent variables are assessed: 1) The type of anticipated stimulus (electric shock or nonpainful vibrotactile); 2) Dental fear level of the subject (low, high); and 3) Sex of the subject. Each of these eight studies (2 stimulus type x 2 fear groups x 2 sex) will be conducted once in the magnetic resonance imaging (MRI) context to assess functional brain activity, and once (with new participants) in a simulated MRI context to acquire autonomic, somatic, and central (i.e., EEG) physiological measures of anticipatory fear. The proposed research will address questions concerning the neural and psychophysiological organization of fear associated with imminent pain, as well as how individual differences in fear and/or sex affect these reactions. The proposed methodology is, furthermore, adaptable and can be used subsequently to address other facets (sensory and emotional) of the pain experience.

描述：提出的实验方案旨在评估的变化

项目成果

Assessing the role of the amygdala in fear of pain: Neural activation under threat of shock.

评估杏仁核在恐惧疼痛中的作用：休克威胁下的神经激活。

• DOI: 10.1016/j.jad.2020.07.110
• 发表时间: 2020
• 期刊: Journal of affective disorders
• 影响因子: 6.6
• 作者: Sambuco,Nicola;Costa,VincentD;Lang,PeterJ;Bradley,MargaretM
• 通讯作者: Bradley,MargaretM

Memory and event-related potentials for rapidly presented emotional pictures.

快速呈现情感图片的记忆和事件相关潜力。

• DOI: 10.1007/s00221-010-2356-6
• 发表时间: 2010
• 期刊: Experimental brain research
• 影响因子: 2
• 作者: Versace,Francesco;Bradley,MargaretM;Lang,PeterJ
• 通讯作者: Lang,PeterJ

Aversive perception in a threat context: Separate and independent neural activation.

威胁环境中的厌恶知觉：独立且独立的神经激活。

• DOI: 10.1016/j.biopsycho.2020.107926
• 发表时间: 2020
• 期刊: Biological psychology
• 影响因子: 2.6
• 作者: Sambuco,Nicola;Costa,VincentD;Lang,PeterJ;Bradley,MargaretM
• 通讯作者: Bradley,MargaretM

Fear-conditioned respiration and its association to cardiac reactivity.

恐惧条件呼吸及其与心脏反应性的关联。

• DOI: 10.1016/j.biopsycho.2008.09.006
• 发表时间: 2009
• 期刊: Biological psychology
• 影响因子: 2.6
• 作者: VanDiest,Ilse;Bradley,MargaretM;Guerra,Pedro;VandenBergh,Omer;Lang,PeterJ
• 通讯作者: Lang,PeterJ