Epigenetic reprogramming of calcified vascular smooth muscle cells as a treatment for vascular calcification

钙化血管平滑肌细胞的表观遗传重编程作为血管钙化的治疗

• 批准号: nhmrc : 2002142
• 金额: $ 128.52万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://researchdata.edu.au/epigenetic-reprogramming-calcified-vascular-calcification/1779858
• 关键词: Epigenetic; reprogramming; calcified; vascular; smooth

Pathological hardening of blood vessels, or vascular calcification, is a frequent and deadly complication of many cardiovascular disorders. It is caused by the irreversible change in mature vascular smooth muscle cells (the main cell type in the blood vessel walls) to a bone-forming cell type. We have now identified a new gene that can potentially revert calcified vascular cells back to their physiological state. This represents a promising new approach for treatment of vascular calcification.

病理性血管硬化，或血管钙化，是许多心血管疾病的常见和致命的并发症。它是由成熟血管平滑肌细胞（血管壁的主要细胞类型）向骨形成细胞类型的不可逆变化引起的。我们现在已经确定了一种新的基因，可以潜在地将钙化的血管细胞恢复到其生理状态。这是一种治疗血管钙化的新方法。