Neural representation of memory for the order of events

事件顺序记忆的神经表征

• 批准号: 6693174
• 负责人: JOSEPH R MANNS
• 金额: $ 4.16万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-15 至 2006-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6693174
• 关键词: electrophysiology; entorhinal cortex; hippocampus; laboratory rat; memory; neural information processing; neurons; postdoctoral investigator; single cell analysis; stereotaxic techniques

DESCRIPTION (provided by applicant): To explore the neural coding mechanisms by which the hippocampal region mediates declarative memory, single neurons will be recorded in behaving rats as they sample a series of stimulus items, then judge either the sequential order or the familiarity of the items on the sample list. I will test the hypothesis that the hippocampus encodes information about the sequential positions of the items whereas the adjacent perirhinal cortex encodes item familiarity (i.e., whether or not the item was on the list). The proposed experiments are guided by recent findings with humans that have been taken as evidence for a selective role for the hippocampus in episodic memory and for the surrounding cortex in semantic memory. Also, recent findings in animals suggest sequence memory is an important feature of hippocampal involvement in episodic memory. A basic understanding of the mechanisms by which long-term memories are encoded by neurons in the hippocampus and surrounding cortex is fundamental to understanding declarative memory and to addressing disorders of memory.

描述（由申请人提供）：为了探索海马区介导陈述性记忆的神经编码机制，将在行为大鼠中记录单个神经元，因为它们对一系列刺激项目进行采样，然后判断样本列表上项目的顺序或熟悉度。我将检验海马体编码关于项目顺序位置的信息，而相邻的嗅周皮层编码项目熟悉性（即，该项目是否在列表上）。建议的实验是由最近的研究结果与人类已被视为证据的选择性作用的海马在情节记忆和周围皮层的语义记忆。此外，最近的研究结果表明，在动物序列记忆是海马参与情节记忆的一个重要特征。对海马体和周围皮层神经元编码长期记忆的机制的基本理解，对于理解陈述性记忆和解决记忆障碍至关重要。