Origin of the dual rate- and phase codes of space in the hippocampus and medial entorhinal cortex

海马和内侧内嗅皮层空间双速率和相位代码的起源

• 批准号: 251236949
• 负责人: Professor Dr. Christian Leibold
• 金额: --
• 依托单位: Division of Biological Sciences
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/251236949?language=en
• 关键词: Origin; dual; rate; phase; codes

Space is neuronally represented in the hippocampal formation both in the firing rate of place-selective neurons and the spike timing with respect to the local field potential oscillation. A multitude of theoretical models exist, which provide possible mechanistic explanations of both codes in several parts of the hippocampal formation. In this project we analyse data from the laboratory of our collaborator, from animals with either hippocampal or medial entorhinal lesions. Since these two brain areas are connected in a loop, the lesioned animals provide an ideal model system to study the computations occurring in the individual brain areas alone. Preliminary results indicate that the medial entorhinal cortex is particularly important for the timing relations in the hippocampus, whereas, in contrast to current believe, it hardly affects the rate code. Analyzing recordings of medial entorhinal cortex neurons in hippocampus-lesioned animals allow us to refine current theoretical models of grid field formation. Particularly the reduction of place-specific firing asks for a new modeling approach. In this project we will develop a new spike-based model of entorhinal grid cells that will be cross-checked by data from hippocampus-lesioned animals.

空间是神经元在海马结构中的位置选择性神经元的放电率和相对于局部场电位振荡的尖峰时间。大量的理论模型存在，这两个代码在海马结构的几个部分提供了可能的机制解释。在这个项目中，我们分析了来自我们合作者实验室的数据，这些数据来自海马或内侧内嗅病变的动物。由于这两个脑区连接在一个回路中，因此受损动物提供了一个理想的模型系统来研究单独在单个脑区中发生的计算。初步结果表明，内侧内嗅皮层是特别重要的时间关系，在海马，而目前认为，它几乎不影响率代码。分析记录的内侧内嗅皮层神经元在海马损伤的动物，使我们能够完善目前的理论模型的网格场的形成。特别是减少特定位置的射击要求一种新的建模方法。在这个项目中，我们将开发一个新的基于尖峰的内嗅网格细胞模型，该模型将通过来自脑损伤动物的数据进行交叉检查。

项目成果

Asymmetry of Neuronal Combinatorial Codes Arises from Minimizing Synaptic Weight Change

神经组合编码的不对称性源于最小化突触权重变化

• DOI: 10.1162/neco_a_00854
• 发表时间: 2016
• 期刊: Neural Computation
• 影响因子: 2.9
• 作者: Leibold;Christian ;Monsalve-Mercado;Mauro M.
• 通讯作者: Mauro M.

Hippocampal CA1 replay becomes less prominent but more rigid without inputs from medial entorhinal cortex

• DOI: 10.1038/s41467-019-09280-0
• 发表时间: 2019-03-22
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Chenani, Alireza;Sabariego, Marta;Leibold, Christian
• 通讯作者: Leibold, Christian