一种新型 M1 毒蕈碱激活剂可治疗阿尔茨海默氏病记忆缺陷-猫眼课题宝

一种新型 M1 毒蕈碱激活剂可治疗阿尔茨海默氏病记忆缺陷

批准号：

8699638

负责人：

JOSEPH R MANNS

金额：

$19.29万

依托单位：

EMORY UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2013

资助国家：

美国

项目状态：

已结题

起止时间：

2013-07-15 至 2016-04-30

来源：

https://reporter.nih.gov/project-details/8699638

关键词：

Acetylcholinesterase Inhibitors Acute Adverse effects Age Aging Agonist Alzheimer&apos s Disease Alzheimer&apos s disease model Amyloid beta-Protein Asses Bioavailable Biological Assay Brain Brain Pathology Cells Cholinergic Agents Cholinergic Receptors Chronic Dementia Deposition Disease Dose Down-Regulation Drug Targeting Functional disorder Goals Hippocampus (Brain)Impaired cognition Individual Lead Masks Memory Memory impairment Muscarinic Acetylcholine Receptor Muscarinic Agonists Muscarinic M1 Receptor Muscarinics Neurobehavioral Manifestations Neurons Nicotinic Receptors Onset of illness Outcome Pathology Patients Pharmaceutical Preparations Pharmacotherapy Population Production Property Pyramidal Cells Quality of life Rattus Regulation Rodent Model Signal Transduction Staging Structure Symptoms Testing Time Training Transgenic Organisms amyloid precursor protein processing awake base cholinergic density desensitization efficacy testing functional restoration graduate student improved in vivo innovation neuropathology novel public health relevance receptor research study small molecule success undergraduate student

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DESCRIPTION (provided by applicant): The objective of the current project is to develop new drug therapies to treat cognitive dysfunction associated with Alzheimer's disease. The goal is to treat symptoms such as memory impairment but also to delay the onset of the brain dysfunction that underlies this cognitive decline. The proposed experiments aim to demonstrate the efficacy of a novel muscarinic M1-specific agonist (VU0364572) in treating hippocampal dysfunction in a rat model of Alzheimer's disease. The approach will focus on in vivo electrophysiological recordings of many individual hippocampal neurons as a sensitive assay of memory functioning. In addition, the proposed experiments aim to demonstrate the efficacy of VU0364572 in delaying the onset of memory impairments and brain pathology in a rat model of Alzheimer's disease. Over the two- year period, the proposed experiments are expected to contribute to the training of one graduate student and two undergraduate students.

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