Effects of Cognitive Control Training on Improving the Long-Term Quality of Life of Breast Cancer Survivors Returning to Work.

正在进行的神经成像研究表明，乳腺癌幸存者采用了诸如加强精神努力和使用大量处理资源等补偿机制来减少“化疗脑”(癌症治疗后可能出现的思维和记忆问题)的毒性影响[1]。来自辅助化疗[2]和/或内分泌治疗[3]的神经毒性减少了与观察到的认知功能障碍相对应的大脑区域的灰质和白质的体积[4]。我提议的研究旨在使用跨诊断路径(一种整合多个学科进行实验研究的路径，可以直接应用于现实世界来解决现有问题)来扩展和扩充现有文献，以探索自适应认知控制训练(CCT)(即双N-Back训练)在减轻重返工作岗位的乳腺癌幸存者注意力控制受损和处理效率降低方面的效果。这项研究有三个主要目的：(1)证实神经认知障碍的模式(使用事件相关电位(ERP)等电生理指标)与自我报告和认知下降的行为中介有关；(2)针对这些机制，使用主动适应性双N-back训练来改善神经认知功能和认知灵活性，对情绪调节策略产生积极影响；(3)确定神经认知训练(双N-back训练)对接受抗癌治疗后重返工作岗位的女性的工作表现结果以及感知能力的影响

Ongoing neuroimaging research has revealed that compensatory mechanisms such as enhanced mental effort and the use of extensive processing resources are employed by breast cancer survivors to diminish the toxic effects of 'chemo-brain' (thinking and memory problems that can occur after cancer treatment) [1]. Neurotoxicity from adjuvant chemotherapy [2] and/or endocrine treatment [3] reduces the volume of grey and white matter in brain regions corresponding to the cognitive dysfunctions observed [4]. My proposed research aims to extend and augment the existing body of literature using a trans-diagnostic pathway (a pathway that integrates multiple disciplines to conduct experimental research that can be directly applied to the 'real world' to resolve an existing issue) to explore the effects of adaptive cognitive control training (CCT) (i.e. dual N-back training) on attenuating impaired attentional control and reduced processing efficiency amongst breast cancer survivors returning to work. The research has three primary aims: (1) To substantiate the pattern of neuro-cognitive impairments (using electrophysiological measures such as event-related potentials (ERP)) associated with both self-report and behavioural mediators of cognitive decline; (2) To target those mechanisms using active adaptive dual N-back training to improve neuro-cognitive function and cognitive flexibility, generating a positive impact on emotion regulatory strategies; (3) To identify the effects of neurocognitive training (dual N-back training) on performance outcomes at work in women returning to work following anticancer treatment as well as perceived competency