Effects of Cognitive Control Training on Improving the Long-Term Quality of Life of Breast Cancer Survivors Returning to Work.

正在进行的神经影像学研究表明，乳腺癌幸存者采用诸如增强精神努力和广泛使用处理资源等代偿机制来减少“化学脑”（癌症治疗后可能出现的思维和记忆问题）的毒性作用。辅助化疗[2]和/或内分泌治疗[3]的神经毒性可减少与观察到的认知功能障碍[4]相应的脑区灰质和白质的体积。我提出的研究旨在利用跨诊断途径（一种整合多学科进行实验研究的途径，可以直接应用于“现实世界”来解决现有问题）扩展和增强现有文献，以探索适应性认知控制训练（CCT）（即双N-back训练）对减轻乳腺癌幸存者重返工作岗位的注意力控制受损和处理效率降低的影响。本研究有三个主要目的：(1)证实与自我报告和认知衰退行为介质相关的神经认知损伤模式（使用事件相关电位（ERP）等电生理测量）；(2)通过主动适应性双N-back训练来改善神经认知功能和认知灵活性，从而对情绪调节策略产生积极影响；(3)探讨神经认知训练（双N-back训练）对女性抗癌治疗后重返工作岗位的绩效结果和感知能力的影响

Ongoing neuroimaging research has revealed that compensatory mechanisms such as enhanced mental effort and the use of extensive processing resources are employed by breast cancer survivors to diminish the toxic effects of 'chemo-brain' (thinking and memory problems that can occur after cancer treatment) [1]. Neurotoxicity from adjuvant chemotherapy [2] and/or endocrine treatment [3] reduces the volume of grey and white matter in brain regions corresponding to the cognitive dysfunctions observed [4]. My proposed research aims to extend and augment the existing body of literature using a trans-diagnostic pathway (a pathway that integrates multiple disciplines to conduct experimental research that can be directly applied to the 'real world' to resolve an existing issue) to explore the effects of adaptive cognitive control training (CCT) (i.e. dual N-back training) on attenuating impaired attentional control and reduced processing efficiency amongst breast cancer survivors returning to work. The research has three primary aims: (1) To substantiate the pattern of neuro-cognitive impairments (using electrophysiological measures such as event-related potentials (ERP)) associated with both self-report and behavioural mediators of cognitive decline; (2) To target those mechanisms using active adaptive dual N-back training to improve neuro-cognitive function and cognitive flexibility, generating a positive impact on emotion regulatory strategies; (3) To identify the effects of neurocognitive training (dual N-back training) on performance outcomes at work in women returning to work following anticancer treatment as well as perceived competency