ENHANCEMENT OF MOLECULAR BIOLOGY RESEARCH FACILITIES

加强分子生物学研究设施

• 批准号: 6588943
• 负责人: LARRY J FORNEY
• 金额: $ 49.98万
• 依托单位: UNIVERSITY OF IDAHO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-23 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6588943
• 关键词: biochemical evolution; functional /structural genomics; proteomics; structural biology

DESCRIPTION (provided by applicant): In February 2002, the UI received funding from the National Institutes of Health (NIH) to establish a COBRE. The funding brings together with expertise in computational biology, computer science and biology to investigate the relative importance of various mutagenic processes on the tempo and trajectory of adaptive evolution, the functional significance of patterns that emerge during the course of evolution, and to develop computational approaches that improve ability to understand the evolutionary history of functional domains in proteins, structural genes, and entire genomes. The funding from the NIH COBRE program has been used to establish the Center for Research on Processes in Evolution (CRePE) at the UI. Requested supplemental funding are to enhance completion and extension of the experimental evolution experiments proposed as an integral part of CRePE. Specifically the funds will be used to: 1) renovate teaching laboratory space to research laboratory space that will be used for expansion of the Core Molecular Biology facility, 2) expand the capabilities of the Core Molecular Biology facility for DNA library construction and screening, DNA sequencing, as well as Southern and Northern hybridization analyses, and 3) acquire equipment useful in studies on the experimental evolution of prokaryotic populations.

描述（由申请人提供）： 2002年2月，UI获得了美国国立卫生研究院（NIH）的资助，建立了COBRE。 该基金汇集了计算生物学，计算机科学和生物学的专业知识，以调查各种诱变过程对适应性进化的克里思和轨迹的相对重要性，进化过程中出现的模式的功能意义，并开发计算方法，提高理解蛋白质，结构基因和整个基因组中功能域的进化历史的能力。 来自NIH COBRE计划的资金已用于在UI建立进化过程研究中心（CRePE）。 所要求的补充资金是为了加强作为CRePE不可分割的一部分而提出的实验性进化实验的完成和扩展。 具体而言，这些资金将用于：1）将教学实验室空间改造为研究实验室空间，用于扩展核心分子生物学设施，2）扩大核心分子生物学设施的能力，用于DNA文库构建和筛选，DNA测序，以及Southern和北方杂交分析，以及3）获得用于原核种群实验进化研究的设备。