Targeting regulatory elements underlying astrocyte-neuron interactions in human

针对人类星形胶质细胞-神经元相互作用的调控元件

• 批准号: 2118894
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2118894
• 关键词: Targeting; regulatory; elements; underlying; astrocyte

I am particularly interested in working with patient specific disease models, especially more complex multilineageconstructs, making this project with Dr Lakatos my preferred choice. This interest was cultivated during my time in theTedesco Lab at UCL, where we are creating multilineage muscle constructs to model skeletal muscle diseases. Thisproject would allow me to further investigate the potential of using organoids for translational research, which isparticularly important to me, as I find the translational aspect of projects highly motivating. My master's module, 'TheNeurobiology of Neurodegenerative Diseases', has developed my fascination with the complexity and different levels ofinteraction that take place in diseases such as ALS, and I think increasing our understanding of the interactions andprogression on an inter-cellular level will be invaluable in moving our understanding forward.

我特别感兴趣的是与患者特定的疾病模型，特别是更复杂的多线结构，使这个项目与博士拉卡托斯我的首选。这种兴趣是在我在伦敦大学学院的特德斯科实验室工作期间培养的，在那里我们正在创建多谱系肌肉结构来模拟骨骼肌疾病。这个项目将使我能够进一步研究将类器官用于转化研究的潜力，这对我来说特别重要，因为我发现项目的转化方面非常有动力。我的硕士课程“神经退行性疾病的神经生物学”使我对ALS等疾病中发生的复杂性和不同水平的相互作用产生了兴趣，我认为增加我们对细胞间相互作用和进展的理解将是推动我们理解的宝贵因素。

项目成果

Harnessing the intracellular immune system against tau pathology

利用细胞内免疫系统对抗 tau 病理学

• DOI: 10.17863/cam.92265
• 发表时间: 2022
• 作者: Miller L

Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue

Tau 蛋白组装体的行为与小鼠神经组织中独立作用的朊病毒样颗粒不同

• DOI: 10.1101/2021.01.13.426340
• 发表时间: 2021
• 作者: Mukadam A