Human Brain Response To Unexpected Events

人脑对意外事件的反应

• 批准号: 6692250
• 负责人: CAROLINE F ZINK
• 金额: $ 2.44万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6692250
• 关键词: behavior test; behavioral /social science research tag; brain electrical activity; clinical research; corpus striatum; dopamine; expectancy; functional magnetic resonance imaging; handedness; human subject; neural information processing; neuropsychology; parietal lobe /cortex; predoctoral investigator; prefrontal lobe /cortex; reinforcer; substantia nigra; visual stimulus

DESCRIPTION (provided by applicant): The coding of unexpected events and prediction errors is essential for efficient behavior as well as necessary for trial-and-error based learning to occur. Given this, understanding where in the brain the coding takes place is highly significant. The midbrain dopamine system projecting to the striatum has been implicated in processing prediction errors, however it remains unclear if this system codes reward prediction errors specifically, or more generally, prediction errors of behaviorally relevant events that interrupt and require a response. The main goal of this study is to use fMRI to investigate processing of unexpected events (including prediction errors) in the human brain and the influence that the behavioral relevance of the stimuli has on the processing. We hypothesize that striatal activity will be modulated by unexpected behaviorally relevant stimuli and prediction errors, irrespective of reward value; striatal activity will not be modulated when the stimuli are behaviorally irrelevant. To test this hypothesis, the following aims will be addressed. AIM #1: To investigate how unexpected rewarding stimuli (money) modulate human brain activity when the stimuli are behaviorally relevant and when they are behaviorally irrelevant; AIM #2: To investigate how human brain activity is modulated by temporal prediction errors of neutral visual stimuli, when the stimuli are behaviorally relevant and when they are behaviorally irrelevant. In a preliminary study, activity in the striatum increased following unexpected (infrequent), non-rewarding visual stimuli, only when the stimuli were behaviorally relevant, i.e. potentially required a response.

描述(由申请人提供)：意外事件和预测错误的编码对于有效的行为以及基于试错的学习的发生是必要的。有鉴于此，了解大脑中编码发生的位置是非常重要的。投射到纹状体的中脑多巴胺系统与处理预测错误有关，然而，目前尚不清楚该系统是否专门编码奖励预测错误，或者更一般地，编码中断并需要反应的行为相关事件的预测错误。本研究的主要目的是使用功能磁共振成像来研究人脑对意外事件(包括预测错误)的加工，以及刺激的行为相关性对加工的影响。我们假设纹状体活动将受到意外的行为相关刺激和预测误差的调节，而与奖赏价值无关；当这些刺激在行为上无关时，纹状体活动将不会被调节。为了验证这一假设，将实现以下目标。目的1：研究意外的奖赏刺激(金钱)在行为相关和行为无关时如何调节人脑活动；目的2：研究中性视觉刺激的时间预测误差如何调节人脑活动。在一项初步研究中，纹状体中的活动在意外(不常见)、无回报的视觉刺激后增加，只有当刺激与行为相关时，即潜在地需要反应时。