Human Brain Response To Unexpected Events

人脑对意外事件的反应

• 批准号: 6829665
• 负责人: CAROLINE F ZINK
• 金额: $ 2.35万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6829665
• 关键词: behavior test; behavioral /social science research tag; brain electrical activity; clinical research; corpus striatum; dopamine; expectancy; functional magnetic resonance imaging; handedness; human subject; neural information processing; neuropsychology; parietal lobe /cortex; predoctoral investigator; prefrontal lobe /cortex; reinforcer; substantia nigra; visual stimulus

DESCRIPTION (provided by applicant): The coding of unexpected events and prediction errors is essential for efficient behavior as well as necessary for trial-and-error based learning to occur. Given this, understanding where in the brain the coding takes place is highly significant. The midbrain dopamine system projecting to the striatum has been implicated in processing prediction errors, however it remains unclear if this system codes reward prediction errors specifically, or more generally, prediction errors of behaviorally relevant events that interrupt and require a response. The main goal of this study is to use fMRI to investigate processing of unexpected events (including prediction errors) in the human brain and the influence that the behavioral relevance of the stimuli has on the processing. We hypothesize that striatal activity will be modulated by unexpected behaviorally relevant stimuli and prediction errors, irrespective of reward value; striatal activity will not be modulated when the stimuli are behaviorally irrelevant. To test this hypothesis, the following aims will be addressed. AIM #1: To investigate how unexpected rewarding stimuli (money) modulate human brain activity when the stimuli are behaviorally relevant and when they are behaviorally irrelevant; AIM #2: To investigate how human brain activity is modulated by temporal prediction errors of neutral visual stimuli, when the stimuli are behaviorally relevant and when they are behaviorally irrelevant. In a preliminary study, activity in the striatum increased following unexpected (infrequent), non-rewarding visual stimuli, only when the stimuli were behaviorally relevant, i.e. potentially required a response.

描述（由申请人提供）：非预期事件和预测错误的编码对于有效行为是必不可少的，并且对于基于试错的学习是必要的。鉴于此，了解大脑中编码发生的位置非常重要。投射到纹状体的中脑多巴胺系统与处理预测错误有关，但目前尚不清楚该系统是否专门编码奖励预测错误，或者更一般地说，编码中断并需要响应的行为相关事件的预测错误。本研究的主要目的是利用功能磁共振成像技术研究人脑对意外事件（包括预测错误）的加工过程，以及刺激的行为相关性对加工过程的影响。我们假设，纹状体活动将调制意外的行为相关的刺激和预测错误，无论奖励值;纹状体活动将不会调制时，刺激行为无关。为了检验这一假设，将讨论以下目标。目标1：调查如何意外奖励刺激（金钱）调制人脑活动时，刺激行为相关，当他们行为无关;目的#2：调查人脑活动是如何调制的中性视觉刺激的时间预测错误，当刺激行为相关，当他们行为无关。在一项初步研究中，纹状体的活动在意外的（不频繁的）非奖励性视觉刺激后增加，只有当刺激与行为相关时，即可能需要响应。