3D OF PATELLAR CARTILAGE & THICKNESS RECOVERY KINETICS AFTER IN VIVO COMPRESSION

髌骨软骨 3D

• 批准号: 6657647
• 负责人: ERIK M SHAPIRO
• 金额: $ 22.55万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6657647
• 关键词: arthritis; bioimaging /biomedical imaging; biomedical resource; building /facility design /renovation; connective tissue; magnetic resonance imaging; nuclear magnetic resonance spectroscopy

Articular Cartilage is a connective tissue primarily composed of collagen fiber bundles , proteoglycan aggregates and water. Articular cartilage functions as the load bearing surface of all synovial joints. The disease process of osteoarthritis involves the degeneration of load bearing articular cartilage. The earliest manifestations of this disease induce changes in the density and mobility of the sodium ions as well as loss of proteoglycan content in the extra-cellular matrix. In general, mechanical behaviour has an important role in the function of synovial joints. This phenomenon is important in the physiological processes involved in chondrocyte nutrition, joint lubrication and etiology of osteoarthritis. The object of this investigation is to determine the visco-elastic response of articular cartilage subjected to pressures and strains close to physiological range using non-invasive MR techniques that employ a specially designed pressure cell. Initially we have conducted the measurements on series of normal bovine specimens as well as enzymatically degraded speciemns. Our priliminary data indicate that articular cartilage compresses with at least two time constants, which is consistent with the intuitive notion that the mechanical properties are non -homogeneous. In fact, we are extending all these non-invasive MR techniques to in vivo and further studies are in progress.

关节软骨是一种结缔组织，主要由 胶原纤维束、蛋白聚糖聚集体和水。 关节型 软骨作为所有滑膜的承载表面 关节。 骨关节炎的发病过程涉及 承重关节软骨退化。 最早的 这种疾病的表现会引起密度和 钠离子的迁移率以及蛋白聚糖含量的损失 细胞外基质。 一般来说，机械行为具有 对滑膜关节的功能具有重要作用。 这种现象是 在软骨细胞的生理过程中很重要 营养、关节润滑和骨关节炎的病因学。 这 这项研究的目的是确定粘弹性 关节软骨对压力和应变的反应 使用非侵入性 MR 技术接近生理范围 采用专门设计的压力传感器。 最初我们有 对一系列正常牛样本进行了测量 以及酶降解的样本。 我们的初步数据 表明关节软骨至少压缩两次 常数，这与直观的概念是一致的 机械性能不均匀。 事实上，我们正在扩展 所有这些非侵入性 MR 技术都可用于体内和进一步研究 正在进行中。