DETERMINE HEAT DEPOSITION BY MRI COILS

通过 MRI 线圈确定热沉积

• 批准号: 6657636
• 负责人: ERIK M SHAPIRO
• 金额: $ 22.55万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6657636
• 关键词: bioimaging /biomedical imaging; biomedical resource; magnetic resonance imaging; nuclear magnetic resonance spectroscopy; technology /technique

The standard method of 17O decoupling uses a spin-echo sequence and therefore requires a volume coil for proper implementation. We have developed a pulse sequence that allows 17O decoupling during a proton stimulated echo (STEAM) sequence. This allows use of a double-tuned surface coil for 17O quantification. Use of a surface coil carries several advantages over the use of a volume coil, including improved signal-to-noise ratios and suitability for studying small volumes of tissue. We have successfully detected natural-abundance 17O in animals using this sequence. Further improvements to the sequence are underway, including adaptation for multi-voxel spectroscopy and imaging.

17 O去耦的标准方法使用自旋回波序列 因此需要体积线圈用于适当的实现。 我们 已经开发出一种脉冲序列，允许17O去耦期间， 质子刺激回波（STEAM）序列。 这允许使用 双调谐表面线圈用于17O定量。 使用表面 线圈具有优于使用体积线圈的几个优点， 包括改善信噪比和适合研究 少量的组织。 我们已经成功探测到 自然丰度17O在动物使用此序列。 进一步 对序列的改进正在进行中，包括适应 多体素光谱和成像。