通过 MRI 线圈确定热沉积-猫眼课题宝

通过 MRI 线圈确定热沉积

批准号：

6349302

负责人：

ERIK M SHAPIRO

金额：

$2.8万

依托单位：

UNIVERSITY OF PENNSYLVANIA

依托单位国家：

美国

项目类别：

财政年份：

2000

资助国家：

美国

项目状态：

已结题

起止时间：

2000-09-01 至 2001-08-31

来源：

https://reporter.nih.gov/project-details/6349302

关键词：

bioimaging /biomedical imaging biomedical resource magnetic resonance imaging nuclear magnetic resonance spectroscopy technology /technique

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英文摘要

The standard method of 17O decoupling uses a spin-echo sequence and therefore requires a volume coil for proper implementation. We have developed a pulse sequence that allows 17O decoupling during a proton stimulated echo (STEAM) sequence. This allows use of a double-tuned surface coil for 17O quantification. Use of a surface coil carries several advantages over the use of a volume coil, including improved signal-to-noise ratios and suitability for studying small volumes of tissue. We have successfully detected natural-abundance 17O in animals using this sequence. Further improvements to the sequence are underway, including adaptation for multi-voxel spectroscopy and imaging.

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