Outcomes of Traumatic Brain Injury in Children

儿童脑外伤的后果

• 批准号: 6605181
• 负责人: KEITH O YEATES
• 金额: $ 10.29万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6605181
• 关键词: adolescence (12-20); behavior; brain injury; child (0-11); children; clinical research; cognition; epidemiology; functional ability; growth /development; human subject; interview; longitudinal human study; problem solving

DESCRIPTION (provided by applicant): The applicant is seeking a K02 (Independent Scientist Award) to continue building a program of research focusing on the outcomes of childhood traumatic brain injury (TBI). His objectives are (1) to investigate how children's development following TBI is related to severity of injury, age at injury, and time since injury; (2) to examine the role of environmental factors as moderators of recovery from TBI; and (3) to study the relationships between focal brain lesions, cognitive and social problem-solving skills, and "real world" social functioning following TBI. He has been a Co-Investigator on a prospective, longitudinal study of moderate to severe TBI in school-age children, and currently is Principal Investigator on an NICHD-funded research grant to study the outcomes of mild closed head injuries (CHI) in children and adolescents (see below). His future research efforts will include studies of TBI in preschool children and of the effects of TBI on children's social development. His proposed career development plan will enhance his skills in statistical methods pertinent to his research, including (a) analysis of longitudinal data, (b) treatment of missing data, and (c) robust statistical methods. He also will obtain additional training in the responsible conduct of research. The specific aims of the research are to examine the (1) natural history, (2) prediction, and (3) consequences of post-concussive symptoms in children with mild CHI. The study will involve 200 8 to 15 year old children with mild CHI and 100 with mild orthopedic injuries not involving the head in a concurrent cohort/prospective research design. The children and their families are assessed four times during the first year post injury (i.e., at 1 week, 1 month, 3 months, and 12 months post-injury). Post-concussive symptoms are assessed using rating scales and interviews, with both children and parents as informants. Predictors of post-concussive symptoms include injury characteristics, cognitive abilities, and non-injury related child and family variables. Outcomes include school performance, health utilization, and other aspects of child and family functioning. The study will examine three major hypotheses: (1) Children with mild CHI display more post-concussive symptoms than children with mild orthopedic injuries. (2) The incidence of post-concussive symptoms is related to (a) injury characteristics, (b) impairments in cognitive skills, and (c) non-injury related child and family factors. (3) Severe post-concussive symptoms are associated with more child disability. The findings will help resolve the scientific controversy regarding the outcomes associated with mild CHI, and will assist physicians and other health care providers in identifying and managing the sequelae of mild CHI.

描述（由申请人提供）：申请人正在寻求K02（独立科学家奖）继续构建一项研究计划，重点是儿童创伤性脑损伤（TBI）。他的目标是（1）调查TBI之后儿童的成长如何与受伤的严重程度，伤害年龄以及受伤以来的时间有关； （2）研究环境因素作为从TBI恢复的主持人的作用； （3）研究焦点脑病变，认知和解决问题的技能以及TBI之后的“现实世界”社会功能之间的关系。他一直是对学龄儿童中度至重度TBI的前瞻性，纵向研究的共同研究，目前是对NICHD资助的研究赠款的首席研究员，以研究儿童和青少年中轻度闭合头部受伤（CHI）的结果（请参阅下文）。他未来的研究工作将包括对学龄前儿童中TBI的研究以及TBI对儿童社会发展的影响。他提出的职业发展计划将提高他在与他的研究相关的统计方法方面的技能，包括（a）纵向数据分析，（b）对缺失数据的处理以及（c）强大的统计方法。他还将在负责任的研究中获得额外的培训。该研究的具体目的是检查（1）自然史，（2）预测和（3）轻度CHI儿童脑震荡症状的后果。这项研究将涉及200 8至15岁的轻度CHI儿童和100个轻度骨科损伤的儿童，不涉及并发同时/前瞻性研究设计。在受伤后的第一年（即1周，1个月，3个月和12个月后，对儿童及其家人进行了四次评估）。使用评分量表和访谈评估了脑震荡后的症状，并以儿童和父母作为线人进行评估。脑震荡后症状的预测因素包括伤害特征，认知能力以及与无伤的儿童和家庭变量。结果包括学校表现，健康利用以及儿童和家庭功能的其他方面。该研究将检查三个主要假设：（1）轻度CHI的儿童比轻度骨科损伤的儿童表现出更多的脑震荡症状。 （2）脑震荡后症状的发生率与（a）伤害特征，（b）认知技能障碍以及（c）非损害相关的儿童和家庭因素有关。 （3）严重的脑震荡症状与更多儿童残疾有关。这些发现将有助于解决有关与轻度CHI相关的结果的科学争议，并将帮助医师和其他医疗保健提供者识别和管理轻度CHI的后遗症。