New Frontiers in Pediatric Traumatic Brain Injury

小儿创伤性脑损伤的新领域

• 批准号: 7224100
• 负责人: KEITH O YEATES
• 金额: $ 3.1万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7224100
• 关键词: Accounting; Address; Age; Arts; Biological; Cause of Death; Child; Childhood; Clinical Management; Clinical Trials; Collaborations; Discipline; Functional disorder; Future; Genomics; Goals; Individual; Intervention; Left; Medical; Outcome; Postdoctoral Fellow; Proteomics; Public Health; Range; Recovery; Rehabilitation therapy; Research; Research Personnel; Scientific Advances and Accomplishments; Students; Time; Translating; Translational Research; Traumatic Brain Injury; Variant; Youth; design; disability; frontier; multidisciplinary; neurobehavioral; neuroimaging; neuropathology; novel strategies; posters; programs; psychologic; psychosocial; relating to nervous system; social; symposium

DESCRIPTION (provided by applicant): Research over the past few decades has resulted in many advances in our understanding and management of the outcomes of pediatric traumatic brain injury (TBI), but prior research has often occurred in separate academic silos, with relatively little integration across domains or disciplines. The scientific advances that have occurred within domains (e.g., genomics and proteomics of neural recovery) are not likely to result in significant progress in the clinical management of children with TBI until they become the topic of collaborative research that cuts across multiple levels of analysis. Thus, the time appears to be ripe for an interdisciplinary conference that promotes integrative and translational research efforts. No recent conference has focused on the 'state-of-the-art' of research on pediatric TBI and promoting networking and collaboration among investigators. The PIs therefore propose a cutting-edge research conference on pediatric TBI. The conference agenda will be designed to promote multi-level, integrative, and translational research, and to encourage both new and established investigators to undertake research consistent with this goal. The conference program will highlight the need to investigate factors across a range of levels (i.e., biological, medical, psychological, social) that account for variations in outcomes following pediatric TBI and to translate the results of research into effective treatments and interventions. The conference will include presentations by individual speakers from multiple disciplines, panel discussions, and poster symposia sessions. The program will address a range of topics: genomics/proteomics; neuropathology and pathophysiology; neuroimaging; medical intervention and clinical trials; neurobehavioral outcomes; psychosocial intervention and rehabilitation. The conference should attract a multidisciplinary audience that includes both established and new investigators, as well as graduate students and postdoctoral fellows. The conference will be designed not so much as a comprehensive review of past research as a forum for presentation of newer approaches that illustrate multi-level, integrative, and translational research and promote such research in the future. Traumatic brain injury (TBI) is a leading cause of death and disability in youth under the age of 15, and therefore represents a major public health problem. Estimates suggest that over 17,000 children are left with permanent disabilities as a result of TBI each year. A cutting-edge research conference will promote a better understanding of the outcomes of childhood TBI and help engender more effective treatment and intervention on behalf of children with TBI.

描述（由申请人提供）：在过去的几十年中，研究在我们对小儿创伤性脑损伤（TBI）结果的理解和管理方面取得了许多进步，但是先前的研究经常在单独的学术筒仓中发生，跨领域或学科的整合相对较小。领域内发生的科学进步（例如，神经恢复的基因组学和蛋白质组学）不太可能在TBI儿童的临床管理中取得重大进展，直到他们成为跨多个分析的协作研究的主题。因此，跨学科会议的时间似乎已经成熟，该会议促进了综合和转化研究工作。最近的会议没有集中于小儿TBI研究的“最新研究”，并促进了研究人员之间的网络和协作。因此，PI提出了一项针对小儿TBI的尖端研究会议。会议议程将旨在促进多层次，综合和翻译研究，并鼓励新的和既定的研究人员进行与这一目标一致的研究。该会议计划将强调需要调查跨多个层次（即生物学，医学，心理，社会）的因素，这些因素解释了儿科TBI后结果的差异，并将研究结果转化为有效的治疗和干预措施。该会议将包括来自多个学科，小组讨论和海报研讨会会议的个人演讲者的演讲。该计划将解决一系列主题：基因组/蛋白质组学；神经病理学和病理生理学；神经影像；医疗干预和临床试验；神经行为结果；社会心理干预和康复。会议应吸引包括既定调查员和新研究人员以及研究生和博士后研究员的多学科受众。该会议的设计不仅仅是对过去的研究的全面审查，而是一个论坛，用于介绍新的方法，这些方法说明了多层次，综合和转化研究，并在未来促进了此类研究。创伤性脑损伤（TBI）是15岁以下青年死亡和残疾的主要原因，因此代表了一个重大的公共卫生问题。估计表明，由于TBI，超过17,000名儿童遭受了永久性残疾。尖端的研究会议将更好地理解儿童TBI的结果，并帮助代表TBI儿童进行更有效的治疗和干预。