COCAINE ADDICTION AND NEURONAL EXCITABILITY

可卡因成瘾和神经元兴奋性

• 批准号: 6628325
• 负责人: Francis White
• 金额: $ 12.34万
• 依托单位: ROSALIND FRANKLIN UNIV OF MEDICINE & SCI
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-03 至 2005-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6628325
• 关键词: cocaine; dendritic cells; dopamine receptor; drug addiction; laboratory mouse; laboratory rat; neurophysiology; nucleus accumbens; prefrontal lobe /cortex; pyramidal tracts; self medication; voltage gated channel

This SSA (K05) application seeks salary support for the applicant to continue and build upon a long-standing (15 yr.) program of research into the neurophysiology of cocaine addiction in animal models. This award would reduce the applicant's teaching and administrative activities in all aspects of his academic pursuits that are not directly related to drug abuse. The candidate has recently taken the Chair of the Department of Cellular and Molecular Pharmacology at Chicago Medical School and is in the process of recruiting a group of researchers focused on the neurobiology of addiction. The first major goal of this SSA is to allow the applicant the necessary time to devote at least 75 percent effort to conducting and administering NIDA-related research activities. The second goal is to allow the applicant to continue the development of his own research program into new and powerful electrophysiological and cellular techniques including dual somatic and dendritic patch clamp recordings and ion imaging. Scientifically, the aims of this project are: 1) To characterize dopamine receptor modulation of somatic voltage-gated channels in both medium spiny neurons (MSNs) of the nucleus accumbens and pyramidal neurons (PNs) of the rodent (rat and mouse) prefrontal cortex (PFC). 2) To determine dopamine receptor modulation of dendritic voltage-gated channels in PFC PNs. 3) To characterize the effects of repeated cocaine self-administration on somatic and dendritic voltage-gated channels. Hopefully, these studies will identify specific neuroadaptations that accompany and perhaps cause cocaine addiction and drug-seeking behavior.

此 SSA (K05) 申请为申请人寻求薪资支持，以继续开展动物模型中可卡因成瘾神经生理学的长期（15 年）研究计划。 该奖项将减少申请人在与药物滥用不直接相关的学术追求的各个方面的教学和管理活动。 该候选人最近担任芝加哥医学院细胞和分子药理学系主任，目前正在招募一组专注于成瘾神经生物学的研究人员。 该 SSA 的第一个主要目标是让申请人有必要的时间投入至少 75% 的精力来开展和管理 NIDA 相关的研究活动。 第二个目标是允许申请人继续将自己的研究计划开发成新的、强大的电生理学和细胞技术，包​​括双体细胞和树突膜片钳记录和离子成像。 从科学角度来说，该项目的目标是：1) 表征啮齿类动物（大鼠和小鼠）前额皮质 (PFC) 的伏隔核中型多棘神经元 (MSN) 和锥体神经元 (PN) 中体细胞电压门控通道的多巴胺受体调节。 2) 确定 PFC PN 中树突电压门控通道的多巴胺受体调节。 3) 表征重复可卡因自我给药对体细胞和树突电压门控通道的影响。希望这些研究能够确定伴随并可能导致可卡因成瘾和药物寻求行为的特定神经适应。