Spectroscopic investigations into nano-scale drug interactions and molecular processes in single living cells and isolated molecules

对单个活细胞和分离分子中纳米级药物相互作用和分子过程的光谱研究

• 批准号: DP140102504
• 负责人: Prof Donald McNaughton
• 金额: $ 28.64万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-08-03
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140102504
• 关键词: Spectroscopic; investigations; into; nano; scale

This project will develop micro-spectroscopy and nano-spectroscopy molecular imaging based techniques to spatially locate and determine the bonding sites of a new range of chemotherapeutic drugs designed to treat cancer and malaria. This project will adopt a translational approach looking first at drug interactions directly with molecules such as DNA. Secondly, investigating these interactions in living cells and finally applying the technology to tissue samples. The outcome of this research will be new drug screening technologies and methodologies to address two of the most devastating diseases to afflict human kind, offering hope to the countless millions suffering from these diseases.

该项目将开发基于微光谱和纳米光谱分子成像的技术，以空间定位和确定旨在治疗癌症和疟疾的一系列新化疗药物的结合位点。该项目将采用翻译方法，首先研究药物与DNA等分子的直接相互作用。其次，研究活细胞中的这些相互作用，并最终将该技术应用于组织样本。这项研究的成果将是新的药物筛选技术和方法，以解决困扰人类的两种最具破坏性的疾病，为无数患有这些疾病的人带来希望。