Ethnopharmacological Studies in Oral Medicine

口腔医学的民族药理学研究

• 批准号: 6420698
• 负责人: MICHAEL David COLVARD
• 金额: $ 9.8万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2005-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6420698
• 关键词: Central America; alternative medicine; analgesics; anesthetics; antiinflammatory agents; antineoplastics; cooperative study; cytotoxicity; data collection methodology /evaluation; drug design /synthesis /production; drug quality /standard; drug screening /evaluation; folk medicine; gastrointestinal pharmacology; health surveys; laboratory mouse; medical indigency; medicinal plants; neoplastic growth; nonhuman therapy evaluation; oral facial pain; oral pharyngeal disorder; peptic ulcer; plant extracts; salivation; xerostomias

DESCRIPTION (Provided by applicant): Aphthous ulcers and oral pain are considered the most frequent oral ulcerative pathologies of the human species. Oral dermatological conditions, oral cancer and xerostomia are significant related oral pathologies and these conditions also produce significant pain and ulcerative conditions within the oral cavity. Few scientific studies exist which survey, identify and assess, in controlled formats, the efficacy of the various phytomedicines, which are used by humans throughout the planet, for the myriad pain and pathological conditions of the oral cavity. Minimal scientific data are available which identifies the medicinally active compounds and histopathological effects of phytomedicines used as treatments for oral pain, ulcer and cancer pathologies. This proposed project intends to observe, survey and identify, the ethno-pharmaceutical oral medicine practices and oral phytomedicinal preparations used by the indigenous peoples and populations of Costa Rica. Initial data will be gathered via a literature- and field-based survey of ethno-pharmaceutial practices of Costa Rican and United States citizens for cancer, ulcerative and pain conditions of the oral cavity. Survey data will provide guidance for the collection and cataloguing of the targeted plant species used during the practice of oral medicine in Costa Rica and the United States. Identified plant materials will be collected, taxonomically identified, extracted, the extracts tested in oral related affections, such as pain, inflammation, cancerous growth, and salivation. An Agreement will be set up between the University of Illinois at Chicago and the Universidad Latina of Costa Rica, to access Costa Rican genetic resources for this proposed study. Active samples will be recollected for fractionation and isolation studies. Promising constituent compounds will be subjected to in vivo and in vitro testing against epidermal keratinocytes cell lines, in mouse tail-flick and cytotoxic assessments to determine efficacy, safety, and potential as analgesic, anesthetic, anti-inflammatory, anti-cancer and anti-xerostomia (sialogogue) drugs. The proposal will form the basis of a program aimed at the discovery and development of botanically derived oral medications for non-microbial originating oral diseases and conditions.

描述(申请人提供)：口腔溃疡和口腔疼痛 被认为是人类最常见的口腔溃疡病理。 口腔皮肤病、口腔癌和口干症是重要的 相关的口腔病理和这些情况也会产生明显的疼痛和 口腔内的溃烂状况。目前几乎没有科学研究 以受控形式调查、确定和评估 各种植物药物，被整个星球上的人类使用，用于 口腔的各种疼痛和病理情况。最小科学 可获得识别药用活性化合物的数据和 用于治疗口腔疼痛的植物药物的组织病理学效应， 溃疡和癌症的病理学。 这项拟议的项目旨在观察、调查和确定 民族药学口腔医学实践与口腔植物医学 哥斯达黎加土著人民和居民使用的制剂。 初始数据将通过基于文献和现场的调查来收集 哥斯达黎加和美国公民的民族药学实践 口腔的癌症、溃疡和疼痛状况。调查数据将 为目标工厂的收集和编目提供指导 哥斯达黎加和美国口腔医学实践中使用的物种 各州。将收集经鉴定的植物材料，对其进行分类鉴定， 提取的提取物在口腔相关的情感方面进行了测试，如疼痛， 发炎、癌变和流口水。将建立一项协议 伊利诺伊大学芝加哥分校和拉丁大学 哥斯达黎加为这项拟议的研究获得哥斯达黎加遗传资源。 活性样品将被重新收集用于分馏和分离研究。 有希望的成分化合物将在体内和体外进行测试 对表皮角质形成细胞系的测试，在小鼠甩尾和 细胞毒性评估，以确定有效性、安全性和潜在的AS 止痛、麻醉、抗炎、抗癌、抗口干 (西洛戈格)毒品。该提案将构成旨在 植物衍生口服药物的发现和发展 非微生物来源的口腔疾病和状况。