Ethnopharmacological Studies in Oral Medicine

口腔医学的民族药理学研究

• 批准号: 6717613
• 负责人: MICHAEL David COLVARD
• 金额: $ 10.23万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6717613
• 关键词: Central America; Central American; alternative medicine; analgesics; anesthetics; antiinflammatory agents; antineoplastics; cooperative study; cytotoxicity; data collection methodology /evaluation; drug design /synthesis /production; drug quality /standard; drug screening /evaluation; folk medicine; gastrointestinal pharmacology; health surveys; laboratory mouse; medical indigency; medicinal plants; neoplastic growth; nonhuman therapy evaluation; oral facial pain; oral pharyngeal disorder; peptic ulcer; plant extracts; salivation; xerostomias

DESCRIPTION (Provided by applicant): Aphthous ulcers and oral pain are considered the most frequent oral ulcerative pathologies of the human species. Oral dermatological conditions, oral cancer and xerostomia are significant related oral pathologies and these conditions also produce significant pain and ulcerative conditions within the oral cavity. Few scientific studies exist which survey, identify and assess, in controlled formats, the efficacy of the various phytomedicines, which are used by humans throughout the planet, for the myriad pain and pathological conditions of the oral cavity. Minimal scientific data are available which identifies the medicinally active compounds and histopathological effects of phytomedicines used as treatments for oral pain, ulcer and cancer pathologies. This proposed project intends to observe, survey and identify, the ethno-pharmaceutical oral medicine practices and oral phytomedicinal preparations used by the indigenous peoples and populations of Costa Rica. Initial data will be gathered via a literature- and field-based survey of ethno-pharmaceutial practices of Costa Rican and United States citizens for cancer, ulcerative and pain conditions of the oral cavity. Survey data will provide guidance for the collection and cataloguing of the targeted plant species used during the practice of oral medicine in Costa Rica and the United States. Identified plant materials will be collected, taxonomically identified, extracted, the extracts tested in oral related affections, such as pain, inflammation, cancerous growth, and salivation. An Agreement will be set up between the University of Illinois at Chicago and the Universidad Latina of Costa Rica, to access Costa Rican genetic resources for this proposed study. Active samples will be recollected for fractionation and isolation studies. Promising constituent compounds will be subjected to in vivo and in vitro testing against epidermal keratinocytes cell lines, in mouse tail-flick and cytotoxic assessments to determine efficacy, safety, and potential as analgesic, anesthetic, anti-inflammatory, anti-cancer and anti-xerostomia (sialogogue) drugs. The proposal will form the basis of a program aimed at the discovery and development of botanically derived oral medications for non-microbial originating oral diseases and conditions.

描述（由申请人提供）：口疮性溃疡和口腔疼痛是 被认为是人类最常见的口腔溃疡病理。 口腔皮肤病、口腔癌和口干症很重要 相关的口腔病变，这些病症也会产生明显的疼痛和 口腔内的溃疡病。科学研究很少 以受控形式调查、识别和评估 全世界人类都在使用各种植物药物， 口腔的无数疼痛和病理状况。最低限度的科学 可获得识别药用活性化合物的数据，并且 用于治疗口腔疼痛的植物药物的组织病理学作用， 溃疡和癌症病理。 该拟议项目旨在观察、调查和识别 民族药物口腔医学实践和口腔植物医学 哥斯达黎加土著人民和居民使用的制剂。 初步数据将通过基于文献和实地的调查来收集 哥斯达黎加和美国公民的民族制药实践 口腔癌症、溃疡和疼痛。调查数据将 为目标植物的收集和编目提供指导 哥斯达黎加和美国口腔医学实践中使用的物种 国家。将收集已识别的植物材料，进行分类学鉴定， 提取物，测试提取物对口腔相关的影响，例如疼痛， 炎症、癌变生长和流涎。将订立协议 伊利诺伊大学芝加哥分校和拉丁大学之间 哥斯达黎加，为这项拟议的研究获取哥斯达黎加的遗传资源。 活性样品将被重新收集以进行分级和分离研究。 有前景的成分化合物将接受体内和体外试验 在小鼠甩尾和实验中针对表皮角质形成细胞系进行测试 细胞毒性评估以确定功效、安全性和潜力 镇痛、麻醉、抗炎、抗癌、抗口干 （唾液酸）药物。该提案将构成一项计划的基础，旨在 植物源口服药物的发现和开发 非微生物源性口腔疾病和病症。

项目成果

Smokeless tobacco-induced lamellar body abnormalities.

无烟烟草引起的层状体异常。

• DOI: 10.1111/j.1601-0825.2005.01211.x
• 发表时间: 2006
• 期刊: Oral diseases
• 影响因子: 3.8
• 作者: Colvard,MD;Ashrafi,SH;Alonge,OK;Cordell,GA
• 通讯作者: Cordell,GA

Disaster medicine training survey results for dental health care providers in Illinois.

伊利诺伊州牙科保健提供者的灾难医学培训调查结果。

• DOI: 10.14219/jada.archive.2007.0206
• 发表时间: 2007
• 期刊: Journal of the American Dental Association (1939)
• 作者: Colvard,MichaelD;Naiman,MelissaI;Mata,Danielle;Cordell,GeoffreyA;Lampiris,Lewis
• 通讯作者: Lampiris,Lewis