Thermal Therapy with Hybrid RF/US Phased Arrays

混合 RF/US 相控阵热疗

• 批准号: 6619905
• 负责人: ROBERT J MCGOUGH
• 金额: $ 23.97万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-01 至 2006-05-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6619905
• 关键词: bioengineering /biomedical engineering; breast neoplasms; clinical biomedical equipment; computer simulation; dogs; drug delivery systems; electromagnetic radiation; hyperthermia therapy; liposomes; mathematical model; metastasis; neoplasm /cancer thermotherapy; phantom model; radiowave radiation; ultrasound therapy

DESCRIPTION (provided by applicant): The goal of this research is to develop thermal therapy modeling techniques and prototype applicators that combine ultrasound (US) and radio-frequency (RF) electro-magnetic (EM) phased arrays which are designed for treating locally advanced cancer in the intact breast. The proposed hybrid RF/US applicators will combine regional RE heating with local US heating to improve the temperature distributions relative to those which are presently achievable in the clinic with adjuvant hyperthermia using RF or US applicators alone. These hybrid RE/US phased array devices will facilitate the clinical application of emerging cancer therapies, including the delivery and release of thermosensitive liposome-encapsulated drugs. The strategy for achieving this goal will: 1. evaluate parametric simulation models of the thermal distributions produced by hybrid RF/US applicators; 2. optimize beamforming approaches for the hybrid RF/US phased array system; and 3. design, develop, and test prototype hybrid RF/US thermal therapy systems for locally advanced breast cancer. The modeling approach will calculate RF field contributions and combine these results with simulations of US fields. The combined heating contributions produced by hybrid RE/US phased arrays will be optimized such that temperature distribution in the target volume is improved and problems with normal tissue heating are reduced or eliminated. The modeling and optimization results will also specify candidate geometries for RF/US phased array systems that target locally advanced cancer in the intact breast. Based on these modeling and optimization results, a prototype hybrid RF/US phased array system will be constructed. Anticipated success with the computer modeling, prototype construction, and preliminary device evaluation will ultimately translate into human clinical trials.

描述(申请人提供)：这项研究的目标是开发热疗建模技术和原型敷贴器，将超声(US)和射频(RF)电磁(EM)相控阵相结合，设计用于治疗完整乳腺的局部晚期癌症。拟议的混合RF/US应用程序将结合区域RE加热和局部US加热，相对于目前仅使用RF或US应用程序辅助热疗在临床上可以实现的温度分布进行改善。这些混合RE/US相控阵设备将促进新兴癌症疗法的临床应用，包括输送和释放热敏性脂质体包裹的药物。实现这一目标的战略将： 1.评估混合射频/超声产生的热分布的参数模拟模型。 涂抹器； 2.优化射频/US混合相控阵系统的波束形成方法； 3.设计、开发和测试局部晚期乳腺癌的RF/US混合热疗系统原型。 建模方法将计算射频场的贡献，并将这些结果与美国场的模拟相结合。混合RE/US相控阵产生的综合加热贡献将得到优化，从而改善目标体积内的温度分布，并减少或消除正常组织加热的问题。建模和优化结果还将指定RF/US相控阵系统的候选几何形状，这些系统针对完整乳腺中的局部晚期癌症。基于这些建模和优化结果，将构建一个射频/US混合相控阵系统的原型。计算机建模、原型构建和初步设备评估方面的预期成功最终将转化为人体临床试验。