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Thermal Therapy with Hybrid RF/US Phased Arrays

混合 RF/US 相控阵热疗

基本信息

批准号：
6914910
负责人：
ROBERT J MCGOUGH
金额：
$ 23.21万
依托单位：
MICHIGAN STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-06-01 至 2007-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6914910
关键词：
bioengineering /biomedical engineering breast neoplasms clinical biomedical equipment computer simulation dogs drug delivery systems electromagnetic radiation hyperthermia therapy liposomes mathematical model metastasis neoplasm /cancer thermotherapy phantom model radiowave radiation ultrasound therapy

项目摘要

DESCRIPTION (provided by applicant): The goal of this research is to develop thermal therapy modeling techniques and prototype applicators that combine ultrasound (US) and radio-frequency (RF) electro-magnetic (EM) phased arrays which are designed for treating locally advanced cancer in the intact breast. The proposed hybrid RF/US applicators will combine regional RE heating with local US heating to improve the temperature distributions relative to those which are presently achievable in the clinic with adjuvant hyperthermia using RF or US applicators alone. These hybrid RE/US phased array devices will facilitate the clinical application of emerging cancer therapies, including the delivery and release of thermosensitive liposome-encapsulated drugs. The strategy for achieving this goal will: 1. evaluate parametric simulation models of the thermal distributions produced by hybrid RF/US applicators; 2. optimize beamforming approaches for the hybrid RF/US phased array system; and 3. design, develop, and test prototype hybrid RF/US thermal therapy systems for locally advanced breast cancer. The modeling approach will calculate RF field contributions and combine these results with simulations of US fields. The combined heating contributions produced by hybrid RE/US phased arrays will be optimized such that temperature distribution in the target volume is improved and problems with normal tissue heating are reduced or eliminated. The modeling and optimization results will also specify candidate geometries for RF/US phased array systems that target locally advanced cancer in the intact breast. Based on these modeling and optimization results, a prototype hybrid RF/US phased array system will be constructed. Anticipated success with the computer modeling, prototype construction, and preliminary device evaluation will ultimately translate into human clinical trials.

描述（由申请人提供）：本研究的目标是开发热治疗建模技术和原型施源器，其结合了联合收割机超声（US）和射频（RF）电磁（EM）相控阵，设计用于治疗完整乳房中的局部晚期癌症。所提出的混合RF/US施加器将联合收割机区域RE加热与局部US加热相结合，以相对于目前在临床上仅使用RF或US施加器辅助热疗可实现的温度分布来改善温度分布。这些混合RE/US相控阵装置将促进新兴癌症疗法的临床应用，包括热敏脂质体封装药物的递送和释放。实现这一目标的战略将： 1.评估混合RF/US产生的热分布的参数模拟模型施用器; 2.优化用于混合RF/US相控阵系统的波束成形方法;以及 3.设计、开发和测试用于局部晚期乳腺癌的混合RF/US热治疗系统原型。该建模方法将计算RF场贡献，并将这些结果与US场模拟联合收割机结合。由混合RE/US相控阵列产生的组合加热贡献将被优化，使得目标体积中的温度分布得到改善，并且正常组织加热的问题被减少或消除。建模和优化结果还将指定RF/US相控阵系统的候选几何形状，这些系统针对完整乳房中的局部晚期癌症。基于这些建模和优化结果，一个原型混合RF/US相控阵系统将被构建。计算机建模、原型构建和初步设备评估的预期成功最终将转化为人体临床试验。