Numerical Modeling of Ultrasonics and Electromagnetics for Therapy and Imaging

用于治疗和成像的超声和电磁学数值模拟

• 批准号: 7388185
• 负责人: ROBERT J MCGOUGH
• 金额: $ 11.56万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7388185
• 关键词: Age; Anatomic Models; Computer Simulation; Computer software; Computers; Development; Devices; Diagnostic Imaging; Drug Delivery Systems; Electromagnetics; Elements; Evaluation; Foundations; Hybrids; Image; Internet; Methods; Modality; Modeling; Output; Phase; Relative (related person); Research; Running; Sampling; Simulate; Software Tools; System; Therapeutic; Therapy Evaluation; Time; Transducers; Ultrasonic Therapy; Ultrasonics; Ultrasonography; Week; base; day; design; electric field; file format; pressure; programs; simulation; software development; therapy design; tool

DESCRIPTION (provided by applicant): The overall objective of this effort is to create a comprehensive package of free software tools for computer simulations of ultrasonic and electromagnetic modalities for therapy and imaging applications. In particular, the software developed within this effort will significantly reduce the computation time required for large ultrasound phased array simulations without increasing the numerical error. These fast ultrasound simulations will reduce the computation time by a factor of four or more for most applications, which is especially important for parametric studies that run for days or weeks on modern desktop computers. The software created will also reduce the software development time required for simulations of biomedical ultrasonic and electromagnetic systems, thereby eliminating duplicated software development efforts by establishing a common framework for the evaluation of therapy and imaging strategies. The specific aims for the R21 phase of this effort are: 1. develop a suite of routines for fast simulations of ultrasound devices and arrays designed for therapeutic applications; 2. create a simulation package that performs fast simulations of ultrasound arrays for diagnostic imaging; and 3. construct interfaces and simulation routines for finite element (FE) and finite difference time domain (FDTD) modeling of electromagnetic (EM) systems designed for thermal therapy and targeted drug delivery. The R33 phase will extend the results of the R21 by a) deriving fast methods for simulating pressure fields produced by curved strip transducers, b) creating new simulation approaches that further reduce the computation times by exploiting redundancies in large array simulations, c) developing new simulation software for nonlinear ultrasound propagation, and d) constructing convenient interface tools and simulation routines for the electromagnetic component of hybrid systems designed for therapy and imaging. In each phase of this effort, simulation routines will be developed, validated, and documented, examples will be provided for simulations of therapy and imaging, and then the software will be distributed through a web portal. The resulting comprehensive software package, which will include a convenient user interface, will facilitate rapid evaluation of ultrasonic and electromagnetic array systems for therapy and imaging research.

描述（由申请人提供）：这项工作的总体目标是创建一个全面的免费软件工具包，用于治疗和成像应用的超声和电磁模态的计算机模拟。特别是，在这项工作中开发的软件将显着减少大型超声相控阵列模拟所需的计算时间，而不会增加数值误差。对于大多数应用程序来说，这些快速超声模拟将减少四倍或更多的计算时间，这对于在现代台式计算机上运行数天或数周的参数研究尤为重要。所创建的软件还将减少生物医学超声和电磁系统模拟所需的软件开发时间，从而通过建立用于评估治疗和成像策略的通用框架来消除重复的软件开发工作。R21阶段的具体目标是：1.开发一套程序，用于快速模拟为治疗应用设计的超声设备和阵列; 2.创建执行用于诊断成像的超声阵列的快速模拟的模拟包;以及3.为设计用于热治疗和靶向药物输送的电磁（EM）系统的有限元（FE）和时域有限差分（FDTD）建模构建接口和仿真例程。R33阶段将通过以下方式扩展R21的结果：a）导出用于模拟弯曲条带换能器产生的压力场的快速方法，B）创建新的模拟方法，通过利用大型阵列模拟中的冗余来进一步减少计算时间，c）开发用于非线性超声传播的新的模拟软件，以及d）为设计用于治疗和成像的混合系统的电磁部件构造方便的接口工具和仿真例程。在这项工作的每个阶段，将开发、验证和记录模拟例程，提供治疗和成像模拟示例，然后通过门户网站分发软件。由此产生的综合软件包，其中将包括一个方便的用户界面，将促进快速评估超声和电磁阵列系统的治疗和成像研究。