The Parameters of Emotional-processing in PTSD

PTSD 中情绪处理的参数

• 批准号: 6643559
• 负责人: BRETT T LITZ
• 金额: $ 12.6万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-29 至 2004-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6643559
• 关键词: Hispanic Americans; behavioral /social science research tag; cues; emotions; female; gender difference; human subject; interview; male; military personnel; neural information processing; pathologic process; patient oriented research; photography; posttraumatic stress disorder; psychophysiology; questionnaires; racial /ethnic difference; southeast Asia; startle reaction; veterans; visual stimulus

DESCRIPTION (provided by applicant): Individuals with PTSD report intense negative emotional reactions when reminded of their trauma and a lack of ability to experience and express emotions, or "emotional numbing." Although there has been extensive research conducted on conditioned negative emotional response to reminders of trauma, there has been little research on emotional numbing, and sparse research on the relationship between these two response classes. The goal of this proposal is to demonstrate a link between the negative affect and defensive behavior cued by reminders of trauma and subsequent emotional-processing dysfunction in PTSD, in men and women with PTSD stemming from service in Vietnam. Special effort will be made to recruit and study Hispanic male veterans with PTSD because this group has been found to be at higher risk for PTSD. Two studies are planned to test various parameters of emotional-processing in PTSD. Study 1 will examine the emotional responses of men and women Vietnam veterans with and without PTSD, under three conditions: a neutral baseline condition, a non-trauma-related stressor condition (a fear film), and a trauma-related prime (war-zone images and sounds). The PTSD groups are expected to exhibit more intense emotional reactions to negatively images only as a result of exposure to the trauma-related prime. The trauma prime should also uniquely suppress positively valenced responses in the PTSD groups. Study 2 is a parametric examination of the threshold of stimulus intensity required to elicit a full range of positive and negative emotion in PTSD. We hypothesize that patients with PTSD are predisposed to require a higher threshold of intensity to elicit positive emotion and a lower threshold for negative affect, and that Hispanic male's with PTSD require a higher threshold for positive and negative emotion. In each study, a variety of psychophysiological indicators of emotional response to standardized emotion eliciting color photographs will be assessed. We pay particular attention to the modulation of startle reflex activity, which has been shown to reliably index the valence of emotional responsivity. In Study 2 we will evaluate the degree of stimulus intensity required to produce startle modulation of positive and negative emotion in PTSD.

描述（由申请人提供）： 患有 PTSD 的人报告强烈 当想起他们的创伤和缺乏时的负面情绪反应 体验和表达情感的能力，或“情感麻木”。虽然 关于条件性负面情绪已经进行了广泛的研究 对于创伤提醒的反应，关于情绪的研究很少 对这两种反应之间关系的研究麻木且稀疏 类。该提案的目标是展示以下内容之间的联系： 由创伤和创伤提醒引起的负面情绪和防御行为 患有 PTSD 的男性和女性随后出现 PTSD 情绪处理功能障碍 源于在越南的服役。将特别努力招募和 研究患有创伤后应激障碍 (PTSD) 的西班牙裔男性退伍军人，因为该群体被发现 患 PTSD 的风险较高。计划进行两项研究来测试各种参数 PTSD 中的情绪处理。研究 1 将检查以下人员的情绪反应： 患有或不患有创伤后应激障碍 (PTSD) 的男性和女性越南退伍军人，在三种情况下： 中性基线条件，非创伤相关的应激条件（恐惧 电影），以及与创伤相关的主要内容（战区图像和声音）。创伤后应激障碍（PTSD）群体 预计会对负面图像表现出更强烈的情绪反应 只是由于暴露于与创伤相关的主要因素。创伤素数 还应该独特地抑制 PTSD 群体中的正价反应。 研究 2 是刺激强度阈值的参数检查 需要在 PTSD 中引发全方位的积极和消极情绪。我们 假设患有 PTSD 的患者倾向于要求更高的 引发积极情绪的强度阈值和引发积极情绪的较低阈值 负面影响，患有 PTSD 的西班牙裔男性需要更高的阈值 对于积极和消极的情绪。在每项研究中，各种 对标准化情绪的情绪反应的心理生理指标 将评估引出的彩色照片。我们特别关注 惊吓反射活动的调节，已被证明可以可靠地 索引情绪反应的效价。在研究 2 中，我们将评估 产生正向惊吓调制所需的刺激强度程度 和创伤后应激障碍（PTSD）中的负面情绪。

项目成果

Emotional-processing in posttraumatic stress disorder II: startle reflex modulation during picture processing.

创伤后应激障碍 II 中的情绪处理：图片处理过程中的惊吓反射调节。

• DOI: 10.1037/0021-843x.113.3.451
• 发表时间: 2004
• 期刊: Journal of abnormal psychology
• 影响因子: 4.6
• 作者: Miller,MarkW;Litz,BrettT
• 通讯作者: Litz,BrettT