Emotional-Processing in Borderline Personality Disorder

边缘性人格障碍的情绪处理

• 批准号: 6838945
• 负责人: BRETT T LITZ
• 金额: $ 17.52万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-20 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6838945
• 关键词: angers; arousal; behavioral /social science research tag; borderline personality disorder; clinical research; electromyography; emotional adjustment; emotions; face expression; galvanic skin response; heart rate; human subject; impulsive behavior; interpersonal relations; patient oriented research; psychological stressor; psychopathology; psychophysiology; visual stimulus

DESCRIPTION (provided by applicant): The DSM-IV criteria of intense anger and affective instability explicitly underscore emotional-processing abnormalities in BPD, while others (such as frantic efforts to avoid abandonment, repeated suicide attempts or gestures, intense and unstable relationships) may be viewed as strategies to cope with or consequences of this core deficit. Despite the centrality of emotional reactivity to the concept of BPD, surprisingly little research has directly examined emotions in individuals with BPD. An exception is the recent investigation of physiological indicators of emotional reactions to standardized images with pleasant, neutral, or unpleasant emotional valence. In these studies, subjects with BPD did not show more intense responses to any of the stimulus categories, failing to support emotional hyper-responsiveness in BPD. In this proposal, we argue that patients with BPD will show emotional hyper-reactivity after being provoked or triggered by a salient interpersonal challenge. The resultant anger, characterized by high arousal and cognitive and behavioral disinhibition will alter appraisal of emotional cues and interfere with otherwise intact emotional capabilities. The primary aim of this proposal is to conduct the necessary developmental work to examine the emotional-processing consequences of exposure to a personally relevant challenge in BPD. We propose to generate ideographic scripts of recent perceived violation experiences from open-ended semi-structured narrative accounts and examine emotional behavior in the laboratory psychophysiologically (facial EMG, heart rate, and skin conductance response) prior and subsequent to the ideographic challenge. A second aim is to develop sets of emotionally evocative stimuli that are consistent with interpersonal schemas hypothesized to be relevant to BPD, which can be used in future research. A panel of expert BPD clinical researchers will select these sets through a standardized, computer-based sorting procedure. A third aim is to provide a graduate student sufficient knowledge and expertise to conduct independent research in emotional-processing in psychopathology, especially personality disorders. To support these aims, we propose to recruit participants from the ongoing Collaborative Longitudinal Study of Personality Disorders (CLPS) and to examine emotional-processing at the psychophysiological laboratory at the National Center for PTSD in Boston.

描述（由申请人提供）：DSM-IV 强烈愤怒和情感不稳定的标准明确强调了 BPD 中的情绪处理异常，而其他标准（例如疯狂地努力避免被遗弃、反复自杀企图或姿势、紧张和不稳定的关系）可能被视为应对这种核心缺陷的策略或后果。尽管情绪反应对于 BPD 概念至关重要，但令人惊讶的是，很少有研究直接检查 BPD 患者的情绪。一个例外是最近对具有愉快、中性或不愉快情绪效价的标准化图像的情绪反应的生理指标的调查。在这些研究中，边缘性人格障碍患者对任何刺激类别都没有表现出更强烈的反应，这不支持边缘性人格障碍患者的情绪过度反应。在这项提案中，我们认为边缘性人格障碍患者在受到显着的人际挑战刺激或触发后会表现出情绪过度反应。由此产生的愤怒，其特征是高度觉醒以及认知和行为去抑制，将改变对情绪线索的评估，并干扰其他完好的情绪能力。该提案的主要目的是进行必要的开发工作，以检查边缘性人格障碍中暴露于个人相关挑战的情绪处理后果。我们建议从开放式半结构化叙述中生成最近感知到的违规经历的表意脚本，并在表意挑战之前和之后在实验室心理生理学上检查情绪行为（面部肌电图、心率和皮肤电导反应）。第二个目标是开发一系列情感唤起的刺激，这些刺激与假设与 BPD 相关的人际模式一致，可用于未来的研究。 BPD 临床研究专家小组将通过基于计算机的标准化排序程序来选择这些集合。第三个目标是为研究生提供足够的知识和专业知识，以进行精神病理学情绪处理的独立研究，特别是人格障碍。为了支持这些目标，我们建议从正在进行的人格障碍协作纵向研究（CLPS）中招募参与者，并在波士顿国家创伤后应激障碍中心的心理生理学实验室检查情绪处理。