A High Performance PET and CT Tomograph

高性能 PET 和 CT 断层扫描仪

• 批准号: 6801114
• 负责人: DAVID W TOWNSEND
• 金额: $ 97.7万
• 依托单位: UNIVERSITY OF TENNESSEE KNOXVILLE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-19 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6801114
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical research; computed axial tomography; computer program /software; digital imaging; human subject; image enhancement; neoplasm /cancer diagnosis; noninvasive diagnosis; patient oriented research; positron emission tomography; whole body imaging /scanning

DESCRIPTION (provided by applicant): To address the difficulties encountered by fusion software in retrospectively co-registering anatomical and functional images for regions of the body other than the brain, we have recently taken a more hardware-oriented approach by directly fusing the technologies of CT and PET. This combined PET/CT prototype has demonstrated in over 250 cancer patient studies the important advantages of routinely performing co-registered anatomical and functional imaging. The studies with the prototype have stimulated commercial development of combined PET/CT scanners and at least two designs that comprise a clinical CT scanner placed in tandem with a clinical PET scanner are now available. While currently available PET technology has demonstrated broad applicability in diagnostic cancer imaging, limitations in spatial and temporal resolution have restricted its utility in cancer research. These limitations have also affected the sensitivity of clinical applications of PET. To date, the major success of PET in oncology has been its ability to identify tumors with relatively high levels of [18F]fluoro-deoxyglucose (18FDG) uptake compared to normal tissues. However, an increasing number of specific PET applications are emerging that require imaging capabilities beyond the current technology. There is a growing demand from both the research and clinical arena to improve PET scanner sensitivity and to identify and accurately localize lower levels of abnormal tracer uptake in increasingly smaller structures. Therefore, we are proposing to address these demands by designing and building a high performance PET scanner with integrated CT technology using the new scintillator lutetium oxy-orthosilicate (LSO). The PET detectors are based on a novel large area panel design that will extend axial coverage and achieve count rate performance significantly exceeding that of current PET scanners. Four detector panels arranged in a hexagonal configuration will allow space for a closer integration of the CT components than has previously been possible with both the initial prototype and the commercial designs. A novel feature of this device is that the CT components will also use LSO as the detector material and cover a larger axial and transaxial field-of-view than current CT scanners. Thus, by achieving a closer integration of PET and CT, an extended axial field-of-view and significantly improved imaging performance, this novel combined PET/CT scanner will open up new areas for the imaging and treatment of cancer.

描述（由申请人提供）： 解决融合软件回顾性遇到的困难 共同配准身体其他区域的解剖和功能图像 与大脑相比，我们最近采取了一种更加面向硬件的方法 直接融合CT和PET技术。这种 PET/CT 组合原型 已在超过 250 名癌症患者研究中证明了其重要优势 常规执行联合配准的解剖和功能成像。这 原型研究刺激了组合技术的商业发展 PET/CT 扫描仪和至少两种构成临床 CT 扫描仪的设计 现在可以与临床 PET 扫描仪配合使用。尽管 目前PET技术已在以下领域表现出广泛的适用性： 诊断癌症成像，空间和时间分辨率的限制 限制了其在癌症研究中的效用。这些限制也 影响了PET临床应用的敏感性。迄今为止，主要 PET 在肿瘤学领域的成功在于它能够通过以下方式识别肿瘤： 与相比，[18F]氟脱氧葡萄糖（18FDG）的摄取水平相对较高 正常组织。然而，越来越多的特定 PET 应用 新兴技术需要超越当前技术的成像能力。 研究和临床领域对改进的需求不断增长 PET 扫描仪灵敏度高，可识别并准确定位较低水平 越来越小的结构中示踪剂的异常吸收。因此，我们 我们建议通过设计和建造一个高 高性能 PET 扫描仪，采用集成 CT 技术，采用全新技术 闪烁体原硅酸镥 (LSO)。 PET 探测器基于 新颖的大面积面板设计，可扩展轴向覆盖范围并实现 计数率性能显着超过当前 PET 扫描仪。 四个探测器面板排列成六角形配置，可留出空间 CT 组件的集成比以前更紧密 最初的原型和商业设计都是可能的。一本小说 该器件的特点是 CT 组件也将使用 LSO 作为 探测器材料并覆盖比探测器更大的轴向和横轴视场 当前的 CT 扫描仪。因此，通过实现 PET 和 CT 的更紧密结合， 扩大轴向视野并显着提高成像性能， 这种新颖的组合 PET/CT 扫描仪将为成像和 癌症的治疗。