Neurophysiological Mechanisms of Motor Skills Learning

运动技能学习的神经生理机制

• 批准号: 6605148
• 负责人: John Kalaska
• 金额: $ 24.47万
• 依托单位: UNIVERSITY OF MONTREAL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6605148
• 关键词: Macaca mulatta; biomechanics; cues; learning; motor neurons; neurophysiology; psychomotor function; response generalization; single cell analysis; stimulus generalization; visual stimulus

DESCRIPTION (provided by applicant): To move the hand from one point to another, the brain controls the arm's movement by relying on neural structures that estimate physical dynamics of the task and transform the desired motion into motor commands. If the hand is holding an object or otherwise interacting physically with the environment, the resulting changes in arm dynamics are taken into account by these structures, resulting in altered motor commands. This suggests that in generating motor commands, the brain relies on internal models that predict the physical dynamics of the arm and the external world. These internal models are adaptive, learned with practice, and appear to be a fundamental part of voluntary motor control. However, very little is known about which neural structures are involved in formation of these internal models or how they learn to represent them. The aim here is to combine behavioral, neurophysiological and mathematical tools to infer how internal models are encoded in the cerebral cortex, by considering tasks in which the physical dynamics of reaching movements are altered. The working hypothesis is that the ability of subjects to learn and generalize motor skills is determined by how different kinematics parameters (e.g., direction, position) are encoded in the global tuning functions of cortical neurons, which in turn determines how error-dependent learning mechanisms adapt the internal models for task dynamics. This hypothesis will be tested in part by relating the observed tuning functions of motor cortical neurons to motor performance of subjects in a variety of tasks. To study the adaptation process itself, specific projects will ask how an error experienced in a given movement affects subsequent movements. These observations permit the definition of generalization functions that describe mathematically how the brain adapts the internal model in response to an error. The shape of this function predicts the tuning properties for movement kinematics of the elements that take part in representing the internal model. The generalization functions will be studied in the parameter spaces of arm position and velocity, and these inferred representations will be compared with the trial-to-trial response variability of motor cortex neurons. Further projects will extend learning from the procedural level of associating task dynamics with arm kinematics, to the cognitive level of linking dynamics to arbitrary cues such as the spatial location or color of visual stimuli.

描述（由申请人提供）：为了将手从一个点移动到另一个点，大脑通过依赖于神经结构来控制手臂的运动，神经结构估计任务的物理动力学并将期望的运动转换为运动命令。如果手拿着一个物体或以其他方式与环境进行物理交互，这些结构会考虑手臂动力学的变化，从而改变运动指令。这表明，在产生运动指令时，大脑依赖于预测手臂和外部世界的物理动力学的内部模型。这些内部模型是自适应的，通过实践学习的，似乎是自愿运动控制的基本组成部分。然而，我们对哪些神经结构参与了这些内部模型的形成，以及它们如何学会表示这些模型知之甚少。这里的目的是通过考虑其中到达运动的物理动力学被改变的任务，将联合收割机行为、神经生理学和数学工具结合起来，以推断内部模型是如何在大脑皮层中编码的。工作假设是受试者学习和概括运动技能的能力是由不同的运动学参数（例如，方向、位置）被编码在皮层神经元的全局调谐函数中，这反过来又决定了错误相关学习机制如何适应任务动态的内部模型。这一假设将部分测试相关的观察到的调谐功能的运动皮层神经元的运动性能的受试者在各种任务。为了研究适应过程本身，特定的项目将询问在给定运动中经历的错误如何影响随后的运动。这些观察允许定义泛化功能，这些功能在数学上描述了大脑如何适应内部模型以响应错误。该函数的形状预测了参与表示内部模型的元素的运动学的调整属性。泛化功能将在手臂位置和速度的参数空间中进行研究，并将这些推断的表示与运动皮层神经元的试验到试验的反应变异性进行比较。进一步的项目将从将任务动态与手臂运动学相关联的程序水平扩展到将动态与任意线索（如视觉刺激的空间位置或颜色）联系起来的认知水平。