Evaluation of MRI Safety for Deep Brain Stimulation

脑深部刺激的 MRI 安全性评估

• 批准号: 6644804
• 负责人: Ali R Rezai
• 金额: $ 47.37万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-15 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6644804
• 关键词: bioimaging /biomedical imaging; brain electronic stimulator; brain imaging /visualization /scanning; diagnosis procedure safety; electrodes; electrophysiology; electrostimulus; lenticular nucleus; magnetic field; magnetic resonance imaging; thalamus

DESCRIPTION (provided by applicant): There is a growing interest in the use of chronic deep brain stimulation (DBS) of the thalamus, globus pallidus, and the subthalamic nucleus for the treatment of medically refractory movement disorders and other neurological and psychiatric conditions. The number of patients undergoing DBS surgeries is anticipated to increase rapidly. Use of magnetic resonance imaging (MRI) is crucial for the management of patients with DBS. Critical studies include verification of lead position, assessment of patients with poor outcomes, evaluation for other intracranial pathologies, and performing functional MRI studies. However, electronically activated devices are generally considered to be contraindicated for patients undergoing MRI, based on reports of adverse effects in the literature. Our primary hypothesis is that parameters can be defined that will enable safe MR imaging in patients with DBS. Building upon our preliminary data, We intend to conduct a comprehensive safety analysis, functional assessment of the stimulation devices, and evaluation of the artifacts produced by the DBS. We will use 1.5 Tesla and 3Tesla MR systems, body radio frequency (RF) and head RF coils to conduct all experiments. Specifically, in-vitro experiments will be performed to assess DBS magnetic field interactions (translational attraction and torque), MRI-related heating (including computer modeling), induced electrical currents, and identification of any effects on device functionality. The artifacts produced by the DBS electrodes will also be quantified. The identification of safe MRI parameters will enable patients with neurostimulation systems to routinely undergo diagnostic MR procedures and allow the use of this important imaging modality for the optimal localization of DBS electrodes.

描述（由申请人提供）： 人们越来越关注使用丘脑、苍白球和丘脑底核的慢性脑深部电刺激（DBS）治疗医学难治性运动障碍和其他神经和精神疾病。预计接受DBS手术的患者数量将迅速增加。使用磁共振成像（MRI）对于DBS患者的管理至关重要。关键研究包括验证电极导线位置、评估结局较差的患者、评价其他颅内病变以及进行功能性MRI研究。 然而，根据文献中的不良反应报告，通常认为电子激活器械禁忌用于接受MRI的患者。我们的主要假设是，可以定义参数，使DBS患者的安全MR成像。基于我们的初步数据，我们打算进行全面的安全性分析、刺激器械的功能评估以及DBS产生的伪影评价。我们将使用1.5特斯拉和3特斯拉MR系统、身体射频（RF）和头部RF线圈进行所有实验。具体而言，将进行体外实验，以评估DBS磁场相互作用（平移引力和扭矩）、MRI相关产热（包括计算机建模）、感应电流以及对器械功能的任何影响的识别。还将量化DBS电极产生的伪影。 安全MRI参数的识别将使植入神经刺激系统的患者能够常规接受诊断性MR程序，并允许使用这种重要的成像模式进行DBS电极的最佳定位。