Evaluation of MRI Safety for Deep Brain Stimulation

脑深部刺激的 MRI 安全性评估

• 批准号: 6795463
• 负责人: Ali R Rezai
• 金额: $ 46.96万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-15 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6795463
• 关键词: bioimaging /biomedical imaging; brain electronic stimulator; brain imaging /visualization /scanning; diagnosis procedure safety; electrodes; electrophysiology; electrostimulus; lenticular nucleus; magnetic field; magnetic resonance imaging; thalamus

DESCRIPTION (provided by applicant): There is a growing interest in the use of chronic deep brain stimulation (DBS) of the thalamus, globus pallidus, and the subthalamic nucleus for the treatment of medically refractory movement disorders and other neurological and psychiatric conditions. The number of patients undergoing DBS surgeries is anticipated to increase rapidly. Use of magnetic resonance imaging (MRI) is crucial for the management of patients with DBS. Critical studies include verification of lead position, assessment of patients with poor outcomes, evaluation for other intracranial pathologies, and performing functional MRI studies. However, electronically activated devices are generally considered to be contraindicated for patients undergoing MRI, based on reports of adverse effects in the literature. Our primary hypothesis is that parameters can be defined that will enable safe MR imaging in patients with DBS. Building upon our preliminary data, We intend to conduct a comprehensive safety analysis, functional assessment of the stimulation devices, and evaluation of the artifacts produced by the DBS. We will use 1.5 Tesla and 3Tesla MR systems, body radio frequency (RF) and head RF coils to conduct all experiments. Specifically, in-vitro experiments will be performed to assess DBS magnetic field interactions (translational attraction and torque), MRI-related heating (including computer modeling), induced electrical currents, and identification of any effects on device functionality. The artifacts produced by the DBS electrodes will also be quantified. The identification of safe MRI parameters will enable patients with neurostimulation systems to routinely undergo diagnostic MR procedures and allow the use of this important imaging modality for the optimal localization of DBS electrodes.

描述(由申请人提供)： 使用丘脑、苍白球和丘脑底核的慢性脑深部刺激(DBS)治疗难治性运动障碍和其他神经和精神疾病越来越受到人们的关注。接受星形外科手术的患者数量预计将迅速增加。磁共振成像(MRI)的使用对于DBS患者的治疗至关重要。关键研究包括验证导联位置，评估预后不良的患者，评估其他颅内病变，以及进行功能磁共振研究。 然而，根据文献中关于不良反应的报道，电子激活的设备通常被认为是接受MRI检查的患者的禁忌。我们的主要假设是，可以定义参数，使DBS患者能够进行安全的磁共振成像。在我们初步数据的基础上，我们打算对刺激设备进行全面的安全性分析、功能评估和对DBS产生的人工制品进行评估。我们将使用1.5特斯拉和3特斯拉磁共振系统、身体射频(RF)和头部射频线圈进行所有实验。具体地说，将进行体外实验，以评估DBS磁场相互作用(平移吸引力和扭矩)、MRI相关加热(包括计算机建模)、感应电流以及识别对设备功能的任何影响。DBS电极产生的伪影也将被量化。 确定安全的MRI参数将使使用神经刺激系统的患者能够常规接受诊断MR程序，并允许使用这一重要的成像方式对DBS电极进行最佳定位。

项目成果

MR safety in patients with implanted deep brain stimulation systems (DBS).

植入深部脑刺激系统 (DBS) 的患者的 MR 安全性。

• DOI: 10.1007/978-3-7091-6081-7_30
• 发表时间: 2003
• 期刊: Acta neurochirurgica. Supplement
• 作者: Sharan,A;Rezai,AR;Nyenhuis,JA;Hrdlicka,G;Tkach,J;Baker,K;Turbay,M;Rugieri,P;Phillips,M;Shellock,FG
• 通讯作者: Shellock,FG