IN VIVO INDUCTION OF HIV SPECIFIC CTL BY DENDRITIC CELLS

树突状细胞体内诱导 HIV 特异性 CTL

• 批准号: 6632152
• 负责人: Nina Bhardwaj
• 金额: $ 84.03万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6632152
• 关键词: AIDS vaccines; HIV infections; antigen presentation; antigen presenting cell; cellular immunity; clinical research; cytotoxic T lymphocyte; dendritic cells; enzyme linked immunosorbent assay; human immunodeficiency virus; human subject; immunologic memory

项目成果

Pathways utilized by dendritic cells for binding, uptake, processing and presentation of antigens derived from HIV-1.

树突状细胞用于结合、摄取、加工和呈递源自 HIV-1 的抗原的途径。

• DOI: 10.1002/eji.200636981
• 发表时间: 2007
• 期刊: European journal of immunology
• 影响因子: 5.4
• 作者: Sabado,RachelL;Babcock,Ethan;Kavanagh,DanielG;Tjomsland,Veronica;Walker,BruceD;Lifson,JeffreyD;Bhardwaj,Nina;Larsson,Marie
• 通讯作者: Larsson,Marie

In vitro priming recapitulates in vivo HIV-1 specific T cell responses, revealing rapid loss of virus reactive CD4 T cells in acute HIV-1 infection.

体外启动重现了体内 HIV-1 特异性 T 细胞反应，揭示了急性 HIV-1 感染中病毒反应性 CD4 T 细胞的快速损失。

• DOI: 10.1371/journal.pone.0004256
• 发表时间: 2009
• 期刊: PloS one
• 影响因子: 3.7
• 作者: LubongSabado,Rachel;Kavanagh,DanielG;Kaufmann,DanielE;Fru,Karlhans;Babcock,Ethan;Rosenberg,Eric;Walker,Bruce;Lifson,Jeffrey;Bhardwaj,Nina;Larsson,Marie
• 通讯作者: Larsson,Marie

Preparation of tumor antigen-loaded mature dendritic cells for immunotherapy.

用于免疫治疗的负载肿瘤抗原的成熟树突状细胞的制备。

• DOI: 10.3791/50085
• 发表时间: 2013
• 期刊: Journal of visualized experiments : JoVE
• 作者: Sabado,RachelLubong;Miller,Elizabeth;Spadaccia,Meredith;Vengco,Isabelita;Hasan,Farah;Bhardwaj,Nina
• 通讯作者: Bhardwaj,Nina

TLR4 engagement during TLR3-induced proinflammatory signaling in dendritic cells promotes IL-10-mediated suppression of antitumor immunity.

• DOI: 10.1158/0008-5472.can-10-3988
• 发表时间: 2011-08-15
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: Bogunovic D;Manches O;Godefroy E;Yewdall A;Gallois A;Salazar AM;Marie I;Levy DE;Bhardwaj N
• 通讯作者: Bhardwaj N

Vaccinia virus inhibits the maturation of human dendritic cells: a novel mechanism of immune evasion.

• DOI: 10.4049/jimmunol.163.12.6762
• 发表时间: 1999-12
• 期刊: Journal of immunology
• 影响因子: 4.4
• 作者: J. Engelmayer;M. Larsson;M. Subklewe;A. Chahroudi;W. Cox;R. Steinman;N. Bhardwaj