Bradykinesia in Parkinson's Disease

帕金森病的运动迟缓

• 批准号: 6623504
• 负责人: GEORGE E. STELMACH
• 金额: $ 28.5万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-15 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6623504
• 关键词: Parkinson's disease; abnormal involuntary movement; basal ganglia; clinical research; electromyography; human subject; muscle contraction; proprioception /kinesthesia; psychomotor function

DESCRIPTION: (provided by applicant) One of the most debilitating aspects of Parkinson?s disease is the inability to initiate and execute movements as intended. The fundamental hypothesis behind the proposed research is that basal ganglia impairments, as reflected in Parkinson?s disease, causes a disruption in motor programming processes. It is postulated that there is increased noise in the basal ganglia that produce abnormal timing, patterning, and synchronization of discharges into the motor cortical areas. These irregularities in turn reduce motor programming capabilities that are reflected as alterations in the microstructure of a goal-oriented movement. We have documented that Parkinson?s patients produce movements that exhibit shortened primary submovement components, which then requires secondary, corrective movements. Seven experiments are proposed which examine whether the altered substructure of movements observed in PD is related to muscle activation patterns, force-force variability relationships, and/or a reduced capability to incorporate proprioceptive information at different stages of movement planning and execution. The results of these experiments will be evaluated in combination to allow us to determine which of these potential causes has the greatest impact on primary submovement distance. The data obtained will be useful in the basic science realm as well as the clinical setting; the former by isolating the various motor deficits associated with PD, which may allow for inferences to be made regarding structure-function relationships. In terms of clinical relevance these results will assist in identifying where practitioner interventions or outcome measures should be targeted.

描述：（由申请人提供）最令人衰弱的方面之一 帕金森病是指无法启动和执行运动 故意的。拟议研究背后的基本假设是 帕金森病所反映的神经节损伤会导致紊乱 在电机编程过程中。推测噪音会增加 在基底神经节中产生异常的时间、模式和 同步放电到运动皮层区域。这些 不规则性反过来会降低反映的电机编程能力 作为目标导向运动的微观结构的改变。我们有 据记载，帕金森病患者的运动表现出缩短 主要的子运动组件，然后需要辅助的、校正的 动作。提出了七个实验来检验是否改变了 PD 中观察到的运动子结构与肌肉激活有关 模式、力-力变化关系和/或能力降低 在运动计划的不同阶段纳入本体感觉信息 和执行。这些实验的结果将在 组合，使我们能够确定这些潜在原因中的哪一个具有 对主要次运动距离影响最大。获得的数据将是 在基础科学领域和临床环境中都很有用；前者 通过隔离与 PD 相关的各种运动缺陷，这可能允许 关于结构-功能关系的推论。按照 临床相关性这些结果将有助于确定从业者在哪里 干预措施或结果措施应当有针对性。