Bradykinesia in Parkinson's Disease

描述：(由申请人提供)最令人衰弱的方面之一 帕金森？S病是指不能发起和执行动作 有意的。这项拟议研究背后的基本假设是 神经节损伤，如帕金森-S病所反映的，会导致分裂 在电机编程过程中。据推测，噪音增加了。 在基底节产生异常的计时，图案，和 运动皮质区域的同步放电。这些 不规则性反过来又降低了所反映的电机编程能力 作为目标导向运动的微观结构的改变。我们有 记录了帕金森症患者？S的运动表现出缩短 主要的子移动组件，然后需要辅助的、更正的 动静。提出了七个实验，以检验改变后的 帕金森病患者运动的亚结构与肌肉激活有关 模式、力-力变异性关系和/或降低的能力 在运动规划的不同阶段整合本体感觉信息 和行刑。这些实验的结果将在#年进行评估 组合在一起，使我们能够确定这些潜在原因中的哪一个具有 对初级运动距离的影响最大。所获得的数据将是 在基础科学领域和临床环境中有用；前者 通过隔离与帕金森病相关的各种运动缺陷，这可能允许 关于结构-功能关系的推论。就.而言 临床相关性这些结果将有助于确定从业者 干预措施或结果措施应有针对性。

DESCRIPTION: (provided by applicant) One of the most debilitating aspects of Parkinson?s disease is the inability to initiate and execute movements as intended. The fundamental hypothesis behind the proposed research is that basal ganglia impairments, as reflected in Parkinson?s disease, causes a disruption in motor programming processes. It is postulated that there is increased noise in the basal ganglia that produce abnormal timing, patterning, and synchronization of discharges into the motor cortical areas. These irregularities in turn reduce motor programming capabilities that are reflected as alterations in the microstructure of a goal-oriented movement. We have documented that Parkinson?s patients produce movements that exhibit shortened primary submovement components, which then requires secondary, corrective movements. Seven experiments are proposed which examine whether the altered substructure of movements observed in PD is related to muscle activation patterns, force-force variability relationships, and/or a reduced capability to incorporate proprioceptive information at different stages of movement planning and execution. The results of these experiments will be evaluated in combination to allow us to determine which of these potential causes has the greatest impact on primary submovement distance. The data obtained will be useful in the basic science realm as well as the clinical setting; the former by isolating the various motor deficits associated with PD, which may allow for inferences to be made regarding structure-function relationships. In terms of clinical relevance these results will assist in identifying where practitioner interventions or outcome measures should be targeted.