Bradykinesia in Parkinson's Disease

描述：（由申请人提供） 帕金森？的疾病是无法启动和执行动作， 故意的这项研究背后的基本假设是， 神经节损伤，就像帕金森病一样的疾病，造成了破坏 在运动编程过程中。据推测， 在基底神经节，产生异常的时间，模式， 同步放电进入运动皮质区。这些 不规则性反过来又降低了反映在大脑中的运动编程能力， 作为目标导向运动微观结构的改变。我们有 记录了帕金森病s患者产生的运动表现出缩短 主要的子移动组件，然后需要辅助的，纠正的 动作七个实验提出了检查是否改变 PD中观察到的运动亚结构与肌肉激活有关 模式、力-力可变性关系和/或降低的能力， 在运动规划的不同阶段结合本体感受信息 和处决这些实验的结果将在 结合起来，使我们能够确定这些潜在原因中的哪一个具有 对主要子移动距离的影响最大。获得的数据将 在基础科学领域以及临床环境中有用;前者 通过隔离与PD相关的各种运动缺陷，这可能允许 关于结构-功能关系的推论。方面 临床相关性这些结果将有助于确定医生 干预措施或成果措施应具有针对性。

DESCRIPTION: (provided by applicant) One of the most debilitating aspects of Parkinson?s disease is the inability to initiate and execute movements as intended. The fundamental hypothesis behind the proposed research is that basal ganglia impairments, as reflected in Parkinson?s disease, causes a disruption in motor programming processes. It is postulated that there is increased noise in the basal ganglia that produce abnormal timing, patterning, and synchronization of discharges into the motor cortical areas. These irregularities in turn reduce motor programming capabilities that are reflected as alterations in the microstructure of a goal-oriented movement. We have documented that Parkinson?s patients produce movements that exhibit shortened primary submovement components, which then requires secondary, corrective movements. Seven experiments are proposed which examine whether the altered substructure of movements observed in PD is related to muscle activation patterns, force-force variability relationships, and/or a reduced capability to incorporate proprioceptive information at different stages of movement planning and execution. The results of these experiments will be evaluated in combination to allow us to determine which of these potential causes has the greatest impact on primary submovement distance. The data obtained will be useful in the basic science realm as well as the clinical setting; the former by isolating the various motor deficits associated with PD, which may allow for inferences to be made regarding structure-function relationships. In terms of clinical relevance these results will assist in identifying where practitioner interventions or outcome measures should be targeted.