Singlet Assisted Diffusion Tensor Imaging (SAD-TI)

单态辅助扩散张量成像 (SAD-TI)

基本信息

  • 批准号:
    2155181
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Studentship
  • 财政年份:
    2019
  • 资助国家:
    英国
  • 起止时间:
    2019 至 无数据
  • 项目状态:
    已结题

项目摘要

Diffusion tensor imaging (DTI) is a magnetic resonance modality that provides unique biologically and clinically important information not available via other modalities, including microstructure and fibre orientation mapping. DTI, for example, is used in tractography to visualize anatomic connections between different parts of the brain. DTI uses a combination of radiofrequency and magnetic field gradient pulses to determine the diffusion tensor of a substance in a medium (in clinical MRI is the diffusion tensor of water in tissues). The whole tensor, and not only the diffusion constant, is sought since diffusion is anisotropic in a medium where the microstructure can infer confinement. By plotting the value of the trace of the diffusion tensor voxel-by-voxel it is then possible to obtain anatomical images where the diffusion of water in different tissues is used as contrast. These images can report on anomalies associated with diseases. DTI (as many other NMR technique) relies on the memory of spin states. These need to survive enough time for the molecule to diffuse in the medium and experience the confinement (no confinement would mean isotropic diffusion). Typically, spin memory is preserved for between a few millisecond and a few seconds. In such short time molecules can only travel up to ~100 and thus only structure of this size and below can infer enough confinement so that diffusion appears anisotropic in DTI experiments. In my laboratory, we have recently developed [1-3] an NMR methodology to overcome such limitation and therefore be able to prolong spin memory for many minutes so to detect confinement in structures of up to 2 mm [2] or probe the tortuosity of the medium as experienced by molecules traveling for millimetres across many pores [3]. We dubbed the technique as singlet-assisted diffusion NMR (SAD-NMR) since singlet is the spin state with a long lifetime. The PhD student will to extend this methodology into the field of DTI. The extended diffusion time available after incorporation of the SAD-NMR method into DTI (SAD-TI) will not only allow the characterisation of the diffusion tensor components with greater accuracy than what currently available, but also, and more interesting, will allow the possibility to visualise connections between large channels, fibres or pores in porous media, including biological tissues. In particular we will apply this technique to study the diffusion of nutrients inside 3D printed scaffoldings holding cells (sample provided by collaborators at QUT in Brisbane, AU). These scaffoldings are under development for tissue engineering purposes but as the cells grow along the support the channels close up and a necrotic core develops. The dimension of those channels (0.5-1 mm) are well above what currently measurable with DTI. The SAD-TI method will instead provide unprecedented data to be used to inform the design of next-generation scaffold architecture.
弥散张量成像(DTI)是一种磁共振成像方式,它提供了其他方式无法提供的独特的生物学和临床重要信息,包括微观结构和纤维取向图。例如,DTI被用于神经束造影,以可视化大脑不同部分之间的解剖连接。DTI使用射频和磁场梯度脉冲的组合来确定介质中物质的扩散张量(在临床MRI中是水在组织中的扩散张量)。由于在微观结构可以推断约束的介质中扩散是各向异性的,所以要寻找整个张量,而不仅仅是扩散常数。通过逐体素绘制扩散张量的迹线值,就可以获得解剖图像,其中水在不同组织中的扩散被用作对比。这些图像可以报告与疾病相关的异常。DTI(和许多其他核磁共振技术一样)依赖于自旋态的记忆。它们需要存活足够的时间,以便分子在介质中扩散并经历约束(没有约束意味着各向同性扩散)。通常,自旋记忆的保存时间在几毫秒到几秒钟之间。在如此短的时间内,分子只能移动到~100,因此只有这个尺寸及以下的结构才能推断出足够的约束,从而使扩散在DTI实验中表现出各向异性。在我的实验室,我们最近开发了[1-3]一种核磁共振方法来克服这种限制,因此能够延长自旋记忆数分钟,从而检测高达2毫米b[3]的结构中的约束,或者探测分子在许多孔隙中行进毫米时所经历的介质扭曲。由于单线态是具有长寿命的自旋态,我们将该技术称为单线态辅助扩散核磁共振(SAD-NMR)。博士生将把这种方法扩展到DTI领域。将萨德-核磁共振方法纳入DTI(萨德- ti)后,延长的扩散时间不仅可以比目前可用的扩散张量分量更准确地表征,而且更有趣的是,可以可视化包括生物组织在内的多孔介质中大通道、纤维或孔隙之间的连接。特别是,我们将应用这项技术来研究3D打印支架保持细胞内营养物质的扩散(样品由澳大利亚布里斯班昆士兰科技大学的合作者提供)。这些支架是为了组织工程的目的而开发的,但是当细胞沿着支架生长时,通道会关闭,坏死的核心会形成。这些通道的尺寸(0.5-1毫米)远远高于目前DTI可测量的尺寸。萨德- ti方法将为下一代支架结构的设计提供前所未有的数据。

项目成果

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其他文献

Internet-administered, low-intensity cognitive behavioral therapy for parents of children treated for cancer: A feasibility trial (ENGAGE).
针对癌症儿童父母的互联网管理、低强度认知行为疗法:可行性试验 (ENGAGE)。
  • DOI:
    10.1002/cam4.5377
  • 发表时间:
    2023-03
  • 期刊:
  • 影响因子:
    4
  • 作者:
  • 通讯作者:
Differences in child and adolescent exposure to unhealthy food and beverage advertising on television in a self-regulatory environment.
在自我监管的环境中,儿童和青少年在电视上接触不健康食品和饮料广告的情况存在差异。
  • DOI:
    10.1186/s12889-023-15027-w
  • 发表时间:
    2023-03-23
  • 期刊:
  • 影响因子:
    4.5
  • 作者:
  • 通讯作者:
The association between rheumatoid arthritis and reduced estimated cardiorespiratory fitness is mediated by physical symptoms and negative emotions: a cross-sectional study.
类风湿性关节炎与估计心肺健康降低之间的关联是由身体症状和负面情绪介导的:一项横断面研究。
  • DOI:
    10.1007/s10067-023-06584-x
  • 发表时间:
    2023-07
  • 期刊:
  • 影响因子:
    3.4
  • 作者:
  • 通讯作者:
ElasticBLAST: accelerating sequence search via cloud computing.
ElasticBLAST:通过云计算加速序列搜索。
  • DOI:
    10.1186/s12859-023-05245-9
  • 发表时间:
    2023-03-26
  • 期刊:
  • 影响因子:
    3
  • 作者:
  • 通讯作者:
Amplified EQCM-D detection of extracellular vesicles using 2D gold nanostructured arrays fabricated by block copolymer self-assembly.
使用通过嵌段共聚物自组装制造的 2D 金纳米结构阵列放大 EQCM-D 检测细胞外囊泡。
  • DOI:
    10.1039/d2nh00424k
  • 发表时间:
    2023-03-27
  • 期刊:
  • 影响因子:
    9.7
  • 作者:
  • 通讯作者:

的其他文献

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