VENTROCAUDAL THALAMUS IN HUMAN PAIN

腹尾丘脑在人类疼痛中的作用

• 批准号: 6639650
• 负责人: Fred Lenz
• 金额: $ 36.79万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-10 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6639650
• 关键词: action potentials; chronic pain; clinical research; heat stimulus; human subject; mechanical pressure; neuromuscular disorder; thalamus

DESCRIPTION (Adapted from the Investigator's Abstract): The proposal is a competing continuation of a subproject in an earlier program project grant (P01 NS32386). The studies aim at continuing the examination of the role of the human somatosensory thalamus (Vc) in pain. The long-term objective is to define the role of thalamic activity in signaling thermal sensations and pain sensations using a combination of neurophysiological and psychophysical techniques. Single unit recordings in Vc are performed in chronic pain patients and patients with movement disorders. Recordings in the latter group are considered as generating control data. Aim 1 examines the properties of spike trains in Vc to painful and nonpainful mechanical and thermal stimuli, in movement disorder patients. They also plan on testing whether the spike train properties change with changes in stimulus intensity and as a function of attention. Aim 2 examines the sensations evoked by electrical stimulation within Vc in movement disorder patients. They will examine the sensations as a function of temporal properties of stimuli in an effort to distinguish between paresthesias, warm, cool, & pain perceptions, and to determine the relationship between temporal patterns and intensity perception, as well as relate the stimulus pattern to the characteristics of the neuronal discharge with the equivalent sensation. Aim 3 examines the same questions as in aims 1 & 2 in the Vc of chronic pain patients to differentiate changes in coding properties between the two groups of subjects.

描述（改编自研究者摘要）：该提案是一个

项目成果

The human thalamic somatic sensory nucleus [ventral caudal (Vc)] shows neuronal mechanoreceptor-like responses to optimal stimuli for peripheral mechanoreceptors.

人类丘脑体细胞感觉核 [腹侧尾部 (Vc)] 对周围机械感受器的最佳刺激表现出类似神经元机械感受器的反应。

• DOI: 10.1152/jn.90990.2008
• 发表时间: 2009
• 期刊: Journal of neurophysiology
• 影响因子: 2.5
• 作者: Weiss,N;Ohara,S;Johnson,KO;Lenz,FA
• 通讯作者: Lenz,FA