Bioinformatics Programs at Minority Institutions

描述（由申请人提供）：本项目的主要目的是 通过广泛的基础，增加少数群体参与生物医学研究 现代计算生物信息学技术转移计划 用于生物医学研究，以选定的少数民族机构，他们的教师 成员和他们的研究生。该计划将创造新的 每年在两个少数民族机构的生物信息学计划，并提供 在其他一些少数民族机构进行了重要的生物信息学培训。 该计划的重点是围绕生物信息学和序列的培训 分析技术，使科学家能够有效地利用大量的 各种基因组测序产生的信息量， 表达和大分子分子序列测定项目 世界培训还将包括分子生物学的介绍。 力学和动力学，这将使训练有素的科学家， 有效利用同源建模，以利用结构 从蛋白质数据库中获得的信息，并有效地利用这些信息， 研究序列、结构和 生物大分子的功能。 拟议的技术转让计划包括三个组成部分， 提供即时和长期的研究机会 提供给少数民族机构的科学家。每一个的目标 三个组成部分是：建立一个多学科的核心小组的教师在 每个机构都有生物信息学的知识和兴趣;建立 生物信息学作为选定机构研究生课程的一部分;以及 将生物信息学程序纳入研究工具库 在选定的机构的特定院系的实验室。的 组成部分是： 1)为期两周的生物信息学暑期研讨会， 少数民族机构; 2)介绍生物信息学作为课程的一个永久的一部分，在两个 少数民族校园每年通过生物信息学合作教学 与上述教师团队的成员一起参加课程;以及 3)为少数民族研究生提供为期五周的研究实习 在校园内完成生物信息学课程的机构， 项目涉及至少一名来自少数民族的教师团队成员 匹兹堡超级计算中心（Pittsburgh Supercomputing Center，PSC）

DESCRIPTION (provided by applicant): The primary aim of this project is to increase minority participation in biomedical research through a broadly based technology transfer program of modern computational bioinformatics techniques used in biomedical research to selected minority institutions, their faculty members, and their graduate students. The proposed program will create new bioinformatics programs at two minority institutions each year and provide significant bioinformatics training at a number of other minority institutions. The proposed program focuses around training in bioinformatics and sequence analysis techniques that allow scientists to make effective use of the vast amount of information being produced by various genome sequencing, gene expression, and macromolecular molecular sequence determination projects around the world. The training will also include an introduction to molecular mechanics and dynamics which will allow the trained scientists to make effective use of homology modeling in order to exploit the structural information available from the protein data bank and to effectively use these powerful techniques for investigating the interplay of sequence, structure, and function of biological macromolecules. The proposed technology transfer program involves three components designed to provide both immediate and long-term increases in the research opportunities available to scientists at minority institutions. The aims for each of the three components are to: create a multidisciplinary core group of faculty at each institution with knowledge and interest in bioinformatics; establish bioinformatics as part of the graduate curriculum at selected institutions; and integrate bioinformatics procedures into the repertoire of research tools used in the laboratories of specific faculty at the selected institutions. The components are: 1) A two week summer workshop in bioinformatics for a faculty teams from minority institutions; 2) Introducing bioinformatics as a permanent part of the curriculum at two minority campuses every year by cooperative teaching of an bioinformatics course with members of the above faculty teams; and 3) A five week research internship for graduate students from the minority institutions who have completed the bioinformatics course on their campus in a project involving at least one of the faculty team members from the minority institution and Pittsburgh Supercomputing Center (PSC) staff members.