Bioinformatics Programs at Minority Institutions

描述(由申请人提供)：本项目的主要目标是 通过广泛的基础研究增加少数群体对生物医学研究的参与 现代计算生物信息学技术转移计划 用于选定的少数民族机构的生物医学研究，他们的教职员工 成员和他们的研究生。拟议的计划将创造新的 每年在两个少数族裔机构开展生物信息学项目，并提供 在其他一些少数族裔机构进行了重要的生物信息学培训。 拟议的计划侧重于生物信息学和序列方面的培训 分析技术使科学家能够有效地利用海量的 各种基因组测序产生的信息量，基因 表达，以及大分子序列测定项目周围 整个世界。培训还将包括对分子的介绍 力学和动力学将使训练有素的科学家能够 有效地利用同源建模来开发结构 从蛋白质数据库获得的信息，并有效地使用这些信息 研究序列、结构和序列之间相互作用的强大技术 生物大分子的功能。 拟议的技术转让方案包括三个组成部分，旨在 在研究机会方面提供即时和长期增长 少数族裔机构的科学家可以使用。每个项目的目标都是 三个组成部分是：创建一个多学科的核心教员小组 每个在生物信息学方面有知识和兴趣的机构；建立 将生物信息学作为选定机构研究生课程的一部分；以及 将生物信息学程序整合到所使用的研究工具库中 在选定机构的特定教员的实验室中。这个 组件包括： 1)为来自以下学院的团队举办为期两周的生物信息学夏季研讨会 少数族裔机构； 2)将生物信息学作为两年制课程的永久组成部分 少数民族校区每年开设一门生物信息学合作教学 与上述教师团队的成员一起参加课程；以及 3)为少数民族研究生提供为期五周的研究实习 在校园内完成生物信息学课程的机构 至少有一名少数族裔教员团队成员参与的项目 机构和匹兹堡超级计算中心(PSC)的工作人员。

DESCRIPTION (provided by applicant): The primary aim of this project is to increase minority participation in biomedical research through a broadly based technology transfer program of modern computational bioinformatics techniques used in biomedical research to selected minority institutions, their faculty members, and their graduate students. The proposed program will create new bioinformatics programs at two minority institutions each year and provide significant bioinformatics training at a number of other minority institutions. The proposed program focuses around training in bioinformatics and sequence analysis techniques that allow scientists to make effective use of the vast amount of information being produced by various genome sequencing, gene expression, and macromolecular molecular sequence determination projects around the world. The training will also include an introduction to molecular mechanics and dynamics which will allow the trained scientists to make effective use of homology modeling in order to exploit the structural information available from the protein data bank and to effectively use these powerful techniques for investigating the interplay of sequence, structure, and function of biological macromolecules. The proposed technology transfer program involves three components designed to provide both immediate and long-term increases in the research opportunities available to scientists at minority institutions. The aims for each of the three components are to: create a multidisciplinary core group of faculty at each institution with knowledge and interest in bioinformatics; establish bioinformatics as part of the graduate curriculum at selected institutions; and integrate bioinformatics procedures into the repertoire of research tools used in the laboratories of specific faculty at the selected institutions. The components are: 1) A two week summer workshop in bioinformatics for a faculty teams from minority institutions; 2) Introducing bioinformatics as a permanent part of the curriculum at two minority campuses every year by cooperative teaching of an bioinformatics course with members of the above faculty teams; and 3) A five week research internship for graduate students from the minority institutions who have completed the bioinformatics course on their campus in a project involving at least one of the faculty team members from the minority institution and Pittsburgh Supercomputing Center (PSC) staff members.