Bioinformatics Programs at Minority Institutions

描述（由申请人提供）：该项目的主要目的是 通过广泛的基础，增加少数群体对生物医学研究的参与 现代计算生物信息学技术转移计划 用于选定的少数族裔机构及其教员的生物医学研究 成员及其研究生。拟议的计划将创造新的 每年在两个少数群体机构开展生物信息学项目，并提供 在许多其他少数群体机构中进行了大量的生物信息学培训。 拟议的计划侧重于生物信息学和序列培训 分析技术使科学家能够有效利用大量数据 各种基因组测序、基因产生的信息量 表达和大分子分子序列测定项目围绕 世界。培训还将包括分子学的介绍 力学和动力学，这将使训练有素的科学家能够 有效利用同源建模来开发结构 从蛋白质数据库中获取信息并有效地利用这些信息 研究序列、结构和序列之间相互作用的强大技术 生物大分子的功能。 拟议的技术转让计划涉及三个组成部分，旨在 提供直接和长期的研究机会增加 可供少数民族机构的科学家使用。每个目标的目标 三个组成部分是： 创建一个多学科核心教师团队 每个对生物信息学有知识和兴趣的机构；建立 生物信息学作为选定机构研究生课程的一部分；和 将生物信息学程序整合到所使用的研究工具库中 在选定机构的特定教师的实验室中。的 组成部分是： 1) 为来自以下国家的教师团队举办为期两周的生物信息学夏季研讨会 少数群体机构； 2）将生物信息学作为二年级课程的永久组成部分 少数民族校园每年通过生物信息学合作教学 与上述教师团队成员一起进行的课程；和 3) 为少数民族研究生提供为期五周的研究实习 在其校园内完成生物信息学课程的机构 项目至少涉及一名来自少数族裔的教职团队成员 机构和匹兹堡超级计算中心 (PSC) 的工作人员。

DESCRIPTION (provided by applicant): The primary aim of this project is to increase minority participation in biomedical research through a broadly based technology transfer program of modern computational bioinformatics techniques used in biomedical research to selected minority institutions, their faculty members, and their graduate students. The proposed program will create new bioinformatics programs at two minority institutions each year and provide significant bioinformatics training at a number of other minority institutions. The proposed program focuses around training in bioinformatics and sequence analysis techniques that allow scientists to make effective use of the vast amount of information being produced by various genome sequencing, gene expression, and macromolecular molecular sequence determination projects around the world. The training will also include an introduction to molecular mechanics and dynamics which will allow the trained scientists to make effective use of homology modeling in order to exploit the structural information available from the protein data bank and to effectively use these powerful techniques for investigating the interplay of sequence, structure, and function of biological macromolecules. The proposed technology transfer program involves three components designed to provide both immediate and long-term increases in the research opportunities available to scientists at minority institutions. The aims for each of the three components are to: create a multidisciplinary core group of faculty at each institution with knowledge and interest in bioinformatics; establish bioinformatics as part of the graduate curriculum at selected institutions; and integrate bioinformatics procedures into the repertoire of research tools used in the laboratories of specific faculty at the selected institutions. The components are: 1) A two week summer workshop in bioinformatics for a faculty teams from minority institutions; 2) Introducing bioinformatics as a permanent part of the curriculum at two minority campuses every year by cooperative teaching of an bioinformatics course with members of the above faculty teams; and 3) A five week research internship for graduate students from the minority institutions who have completed the bioinformatics course on their campus in a project involving at least one of the faculty team members from the minority institution and Pittsburgh Supercomputing Center (PSC) staff members.