SHORT-TERM TRAINING FOR MINORITY STUDENTS

该提案响应了国家心肺和血液研究所的及时倡议，以增加心血管疾病研究中代表性不足的少数民族的人数。拟议的培训将在各个心血管疾病研究领域对少数民族学生进行接触、培训和指导。心血管疾病是导致美国人口死亡的主要原因，每年夺去98万多人的生命，少数民族受到的影响尤其严重，尤其是非洲裔美国人。该提案旨在通过招募、强化培训和指导有才华的少数民族学生参与心血管实验治疗和药理学的研究项目，来解决少数民族代表性不足的问题。药学院将利用其在美国国立卫生研究院资助的暑期少数民族生物医学研究实习计划中的丰富经验，该计划已连续三年（1995-1998）实施，以增加少数民族进入生物医学科学职业的人数。每年，在总共五年的时间里，八(8)名在大学度过至少一年的少数民族本科生将被招募到密西西比大学药学院药物化学和药理学系的心血管研究项目中。这些受训者将在美国国立卫生研究院（NIH）、美国心脏协会（American Heart Association）和其他资助的研究项目中接受为期三个月的培训，内容涉及肾上腺素能受体药理学、α和β肾上腺素能受体特异性激动剂和拮抗剂的生化机制、新型腺苷转运阻滞剂、一氧化氮合酶和补体系统抑制剂的设计，以预防缺血/再灌注损伤和/或心脏异种移植排斥反应。将采取积极措施，通过导师鼓励和建议、实地考察、邀请演讲者、研讨会和/或榜样、海报会议等方式，培养学员对心血管研究的兴趣，并引导他们从事心血管研究。将制定计划，跟踪学员，评估项目的成功，并在必要时进行改变。招聘将在密西西比州的社区学院和大学进行。将与附属机构建立联系和直接联系，建立在已经建立的强大网络的基础上，如密西西比少数民族参与联盟，密西西比大学是该联盟的成员。该计划将在每个培训期间和之后通过广泛的调查进行评估。学生和导师将收到问卷。参与者将被跟踪10年以评估该计划。

This proposal responds to the timely initiative of the National Heart Lung and Blood Institute to increase the number of underrepresented minorities in cardiovascular disease research. the proposed training will be expose, train and mentor minority students in various cardiovascular disease research areas. cardiovascular disease is the number cause of death among the American population, taking the lives of over 980,000 people a year, minorities being disproportionately affected, especially African-Americans. The proposal seeks to address the problem of minority underrepresentation through both the recruitment, and intensive training and mentoring of talented minority students in research projects that are focused on cardiovascular experimental therapeutics, and pharmacology. The School of Pharmacy will draw from its extensive experience in the NIH-funded Summer Minority Biomedical Research Internship Program, which has been in place for three consecutive years (1995-1998), to increase the pool of minorities entering into careers in the biomedical sciences. Each year, for a total of five years, eight (8) minority undergraduate students who have spent at least one year in college, will be recruited into the cardiovascular research programs at the University of Mississippi School of Pharmacy, in the Department of Medicinal Chemistry and Pharmacology. These trainees will spend three summer months immersed in training under a faculty mentor, on NIH, American Heart Association, and other funded research projects in adrenergic receptor pharmacology, biochemical mechanisms of alpha- and beta-adrenergic receptor specific agonists and antagonists, the design of novel adenosine transport blockers, nitric oxide synthase and complement system inhibitors for prevention of ischemia/reperfusion injury and/or cardiac xenograft rejection. Proactive steps will be taken to create interest in, and guide trainees to pursue careers in cardiovascular research through mentor encouragement and advising, field trips, invited speakers seminars and/or role models, and poster sessions. Plans will be put in place to track trainees to evaluate the program's success, and to effect changes as deemed necessary. Recruitment will be in- state, from community colleges and universities in Mississippi. Liaisons and direct contacts will be established with feeder institutions, building on already established strong networks like the Mississippi Alliance for Minority Participation of which the University of Mississippi is a member. The program will be evaluated by extensive surveys during and after each training period. Students and mentors will be given questionnaire. Participants will be tracked for 10 years to assess program.