Lab-Grown Leather: Tissue engineering leather using biomaterials textile technologies and 3D cell culture

实验室种植皮革：使用生物材料纺织技术和 3D 细胞培养的组织工程皮革

• 批准号: 2192059
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2192059
• 关键词: Lab; Grown; Leather; Tissue; engineering

The demand for leather in the fashion industry far outweighs current supply. In addition, the use of animals and the tanning process involved for leather production conjures cultural, ethical and environmental issues. Biomaterials and tissue engineering are research areas widely exploited for creating scaffolds to regenerate or replace tissues, such as bone, tendons and skin. The methodologies developed could be readily teamed with textile technologies to create highly innovative lab-grown leather, which would overcome current limitations with supply and ethics. The principal aim of this project is the pairing of a synthetic scaffold with 3D cell culture techniques to produce a new uniformed textile-cell construct or 'leather'.This study will enable traditional fibre-scaffolds to be transformed into unique fabrics using textile processes. These biodegradable fabrics will be subsequently cultured with fibroblasts, which will secrete extracellular matrix proteins (including collagen and elastin) and eventually modify it to be comparable to the dermis layer of the skin. This 'artificial' skin will then be subjected to traditional tanning processes minus a number of previously essential steps to create a mechanically stable, uniform leather material.A major goal will be the understanding of the physical properties of the engineered leather as elucidated using state of the art materials, textile and cell-based characterisation techniques. The key features of the lab grown leather properties and how they are influenced by the tanning process will then be assessed. This project will involve advanced textile, cell culture, material characterisation, as well as development of novel tanning techniques. The University of Manchester is one of only two in the UK with a KES-FB textile testing equipment, offering the opportunity to effectively test performance properties of the new textile material. This is necessary as subjective assessment (visual appearance) is the most common method of quality control used in the sorting and selecting of leather hides. This cross-disciplinary project links two independent research groups at the University of Manchester (Textiles and Biomaterials) and one at the University of Liverpool (Biomaterials). This highly innovative research project will set the foundation for development and expansion of lab-grown textile materials for diverse fashion and technical textile applications.

时尚业对皮革的需求远远超过目前的供应。此外，动物的使用和皮革生产中涉及的制革过程引发了文化、伦理和环境问题。生物材料和组织工程是被广泛开发的研究领域，用于创造支架来再生或取代组织，如骨骼、肌腱和皮肤。开发的方法可以很容易地与纺织技术相结合，创造出高度创新的实验室培育的皮革，这将克服目前供应和道德方面的限制。该项目的主要目标是将合成支架与3D细胞培养技术配对，以生产出一种新的统一的纺织细胞结构或“皮革”。这项研究将使传统的纤维支架能够通过纺织工艺转变为独特的织物。这些可生物降解的面料随后将与成纤维细胞一起培养，成纤维细胞将分泌细胞外基质蛋白(包括胶原和弹性蛋白)，并最终将其修改为与皮肤的真皮层相当。然后，这种“人造”皮肤将经过传统的制革过程，不包括一些以前必须的步骤，以创造出机械稳定、均匀的皮革材料。一个主要目标是了解利用最先进的材料、纺织品和基于细胞的表征技术阐明的工程皮革的物理特性。然后将评估实验室培养的皮革的关键特性以及它们如何受到制革过程的影响。该项目将涉及先进的纺织、细胞培养、材料特性以及新型制革技术的开发。曼彻斯特大学是英国仅有的两所拥有KES-FB纺织品测试设备的大学之一，为有效测试这种新型纺织材料的性能提供了机会。这是必要的，因为主观评价(视觉外观)是皮革分类和选择中最常用的质量控制方法。这个跨学科的项目将曼彻斯特大学的两个独立研究小组(纺织和生物材料)和利物浦大学的一个独立研究小组(生物材料)联系在一起。这一极具创新性的研究项目将为开发和扩大用于各种时尚和技术纺织应用的实验室培育的纺织材料奠定基础。