Epidemiology of hepatocellular carcinoma

肝细胞癌的流行病学

• 批准号: 6654909
• 负责人: CYNTHIA W KO
• 金额: $ 13.12万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-06 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6654909
• 关键词: cancer risk; chronic disease /disorder; clinical research; cofactor; gene mutation; genetic susceptibility; hepatitis C; hepatocellular carcinoma; hereditary hemochromatosis; human subject; iron disorder; liver disorder; longitudinal human study; medical outreach /case finding; neoplasm /cancer epidemiology; neoplasm /cancer genetics; phlebotomy; polymerase chain reaction; questionnaires

DESCRIPTION (provided by applicant): The goals of the proposed research project are: 1) to prepare and train the candidate for a career in academic gastroenterology by providing the necessary environment, education, and research support, and 2) to gain insight into the epidemiology of hepatocellular carcinoma in the United States. The candidate is a clinically trained gastroenterologist with additional training in basic epidemiology and biostatistics. As part of this proposal, she will be provided with more advanced training in both general and applied epidemiology and biostatistics. The candidate will be supported and mentored by Dr. John Potter. Her progress will be monitored by the sponsor and the Division of Gastroenterology. The Department of Medicine and Division of Gastroenterology will provide full commitment and support toward the development of the candidate's independent research career. The focus of the scientific portion of this proposal is on hepatocellular carcinoma, a common tumor worldwide the incidence of which is also rising in the United States. Much of this increase can be attributed to the current epidemic of hepatitis C. The epidemiology of hepatocellular carcinoma has not been extensively studied in this country, and few studies have recruited population-based cases and controls. Well-recognized environmental risk factors for hepatocellular carcinoma include chronic viral hepatitis, other chronic liver diseases, and exposure to aflatoxins. However, risk factors that predispose patients with chronic liver disease to hepatocellular carcinoma are not well defined. It is likely that genetic risk factors for hepatocellular carcinoma exist, since familial and ethnic clustering of the tumor are well documented, iron is a recognized co-factor for the development of malignancy in other sites. Hemochromatosis is an inherited disorder in which excess iron accumulates in the liver, heart, pancreas, and other organs. A gene for hemochromatosis, HFE, has recently been identified. Patients with hemochromatosis are at up to 200-fold increased risk of developing hepatocellular carcinoma. We hypothesize that HFE mutations are risk factors for HCC in patients either with or without underlying liver disease. Thus, the specific aims of tills proposal are: 1) to determine whether mutations in the HFE gene are a risk factor for hepatocellular carcinoma; and 2) to recruit a cohort of patients with chronic hepatitis C for prospective studies of the epidemiology of hepatocellular carcinoma.

描述(由申请人提供)：拟议研究的目标 项目有：1)为学术生涯做好准备和培训 通过提供必要的环境、教育和 研究支持，以及2)深入了解艾滋病的流行病学 美国的肝细胞癌。候选人是一名临床医生。 训练有素的胃肠病专家，接受过基础流行病学和 生物统计学。作为这项提议的一部分，她将获得更多 一般流行病学和应用流行病学及生物统计学方面的高级培训。 候选人将得到约翰·波特博士的支持和指导。她的进步 将由赞助商和消化内科进行监测。这个 医学部和消化科将提供完整的 承诺和支持候选人的独立性发展 研究生涯。 这项提案的科学部分的重点是肝细胞 癌症是世界范围内的一种常见肿瘤，其发病率在 美国。这一增长在很大程度上可以归因于当前的 丙型肝炎的流行。肝细胞癌的流行病学尚未 在这个国家得到了广泛的研究，但很少有研究招募 以人口为基础的病例和对照。公认的环境风险 导致肝细胞癌的因素包括慢性病毒性肝炎、其他 慢性肝病，以及接触黄曲霉毒素。然而，风险因素 使慢性肝病患者易患肝细胞癌 癌症的定义不是很清楚。很可能遗传风险因素对 肝细胞癌的存在，因为家族和民族聚集的 肿瘤有很好的文献记载，铁是公认的促进肿瘤发展的辅助因素 其他部位的恶性病变。血色沉着症是一种遗传性疾病 过量的铁累积在肝脏、心脏、胰腺和其他器官中。 最近发现了一种引起血色素沉着症的基因--HFE。患有疾病的患者 血色沉着症的发病风险高达200倍。 肝细胞癌。我们假设HFE突变是危险因素 对于有或没有潜在肝病的患者的肝细胞癌。因此， TILS方案的具体目标是：1)确定基因突变是否 HFE基因是肝细胞癌的危险因素；和2)招募 慢性丙型肝炎患者队列的前瞻性研究 肝细胞癌的流行病学。