Epidemiology of hepatocellular carcinoma

肝细胞癌的流行病学

• 批准号: 6937690
• 负责人: CYNTHIA W KO
• 金额: $ 13.12万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-06 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6937690
• 关键词: cancer risk; chronic disease /disorder; clinical research; cofactor; gene mutation; genetic susceptibility; hepatitis C; hepatocellular carcinoma; hereditary hemochromatosis; human subject; iron disorder; liver disorder; longitudinal human study; medical outreach /case finding; neoplasm /cancer epidemiology; neoplasm /cancer genetics; phlebotomy; polymerase chain reaction; questionnaires

DESCRIPTION (provided by applicant): The goals of the proposed research project are: 1) to prepare and train the candidate for a career in academic gastroenterology by providing the necessary environment, education, and research support, and 2) to gain insight into the epidemiology of hepatocellular carcinoma in the United States. The candidate is a clinically trained gastroenterologist with additional training in basic epidemiology and biostatistics. As part of this proposal, she will be provided with more advanced training in both general and applied epidemiology and biostatistics. The candidate will be supported and mentored by Dr. John Potter. Her progress will be monitored by the sponsor and the Division of Gastroenterology. The Department of Medicine and Division of Gastroenterology will provide full commitment and support toward the development of the candidate's independent research career. The focus of the scientific portion of this proposal is on hepatocellular carcinoma, a common tumor worldwide the incidence of which is also rising in the United States. Much of this increase can be attributed to the current epidemic of hepatitis C. The epidemiology of hepatocellular carcinoma has not been extensively studied in this country, and few studies have recruited population-based cases and controls. Well-recognized environmental risk factors for hepatocellular carcinoma include chronic viral hepatitis, other chronic liver diseases, and exposure to aflatoxins. However, risk factors that predispose patients with chronic liver disease to hepatocellular carcinoma are not well defined. It is likely that genetic risk factors for hepatocellular carcinoma exist, since familial and ethnic clustering of the tumor are well documented, iron is a recognized co-factor for the development of malignancy in other sites. Hemochromatosis is an inherited disorder in which excess iron accumulates in the liver, heart, pancreas, and other organs. A gene for hemochromatosis, HFE, has recently been identified. Patients with hemochromatosis are at up to 200-fold increased risk of developing hepatocellular carcinoma. We hypothesize that HFE mutations are risk factors for HCC in patients either with or without underlying liver disease. Thus, the specific aims of tills proposal are: 1) to determine whether mutations in the HFE gene are a risk factor for hepatocellular carcinoma; and 2) to recruit a cohort of patients with chronic hepatitis C for prospective studies of the epidemiology of hepatocellular carcinoma.

描述（由申请人提供）：拟议研究的目标 项目是：1）准备和培训候选人的职业生涯在学术 胃肠病学通过提供必要的环境，教育， 研究支持，2）深入了解流行病学， 肝细胞癌在美国候选人是临床上 受过基础流行病学培训的胃肠病学家， 生物统计学作为这项建议的一部分，她将获得更多的 在普通和应用流行病学和生物统计学方面的高级培训。 候选人将得到约翰·波特博士的支持和指导。她的进步 将由申办者和胃肠病学部门进行监测。的 内科及消化科将提供全面的 对候选人独立发展的承诺和支持 研究生涯。 该提案的科学部分重点是肝细胞 癌症是世界范围内常见的肿瘤，其发病率也在上升， 美国的这一增长在很大程度上可以归因于目前的 丙型肝炎的流行肝细胞癌的流行病学还没有 在这个国家被广泛研究，很少有研究招募 基于人群的病例和对照。公认的环境风险 肝细胞癌的因素包括慢性病毒性肝炎，其他 慢性肝脏疾病和接触黄曲霉毒素。然而，风险因素 使慢性肝病患者易患肝细胞癌 癌的定义不明确。很可能是遗传风险因素 肝细胞癌的存在，因为家族和种族聚集性， 肿瘤是有据可查的，铁是公认的发展的辅助因素 其他部位的恶性肿瘤。血色病是一种遗传性疾病， 过量的铁积累在肝脏、心脏、胰腺和其他器官中。 血色素沉着症的基因HFE最近被鉴定出来。患者 血色素沉着症发展风险高达200倍 肝细胞癌我们假设HFE突变是危险因素 对于有或无基础肝病的HCC患者。因此，在本发明中， 该提案的具体目标是：1）确定 HFE基因是肝细胞癌危险因素; 2）招募 慢性丙型肝炎患者队列的前瞻性研究， 肝癌的流行病学