To explore synthetic biology approaches for in vivo data storage

研究方法为了达到我的研究目标，我正在进行以下工作：*数据收集和分析如何修改当前的设计，使其与细胞内的机器一起工作，同时保持保护。*在原核生物中测试其性能的实验（大肠杆菌是我们将开始的原核生物）我使用了许多合成生物学过程和纳米技术概念来实现这一目标。合成生物学是重新设计或创造新的生物系统，而纳米技术是在纳米尺度上创造设备。传统的数据存储介质包括光学、磁性和半导体存储器。它的主要问题是即将到来的“数据启示录”。所谓的“数据启示录”是指社会耗尽数据存储的事件。当数据创建当前超过数据存储介质时，可能会发生此事件。目前的数据创建速度是每天2.5万亿字节，相当于10^18字节。这与传统数据存储的环境成本相结合，许多分析师预测，数据中心的温室气体排放量占全球温室气体排放量的2%，相当于航空业。这种情况只会变得更糟，特别是在现代生活中越来越依赖互联网和其他技术。因此，一项新技术是必要的。2013年初，利用DNA（脱氧核糖核酸）存储信息的想法开始获得资金，因为它的信息更密集，更环保。目前用于在DNA上存储信息的方法使用编码算法和解码算法将信息“写入”到核苷酸上。我的项目旨在通过研究合成生物学的计算机辅助设计和DNA/RNA纳米技术的编组来改进、优化和扩展目前的技术水平。未来的应用在整个过程中，我将开发几个新的过程，例如如何设计DNA和RNA结构，使它们在原核生物中兼容，这不仅与体内数据存储有关，而且可以在医疗治疗行业中应用，仅其中一个。

Approach to researchIn order to reach my research, aim I am conducting the following:* Data gathering and analysis of how to modify the current design so that it will work with the machinery within the cell whilst remaining protected.* Experiments to test its performance in prokaryotes (E. coli is the prokaryote we will start with)I am using many synthetic biology processes and nanotechnology concepts to achieve this. Synthetic biology is the redesigning or creation of new biological systems and nanotechnology is the creation of devices on a nanoscaleBackgroundTraditional data storage media comprises of optical, magnetic and semiconductor memory. The major problem with it is the incoming "Data Apocalypse". The "Data Apocalypse" is a so-called event that society runs out of data storage. This event could happen as data creation is currently outstripping data storage media. Data creation is currently trending at a rate of 2.5 quintillion bytes per day which equates 10^18 Bytes. This is combined with the environmental cost of traditional data storage, it has been forecasted by many analysts that data centres are responsible for 2% of the global greenhouse gas emissions, making them equivalent to the aviation industry. This is only predicted to get worse especially with the ever-increasing dependency on the internet and other technologies in modern day life. Thus, a new technology is necessary. In early 2013, the idea of using DNA (Deoxyribonucleic Acid) to store information started to gather funding as its more information dense and environmentally friendlier. The method currently used to store information on DNA uses an encoding algorithm and decoding algorithm to "write" bits of information onto nucleotides. My project seeks to improve, optimise and extend the state of the art by looking at computer aided design for synthetic biology and the marshalling of DNA/RNA nanotechnologies.Future applicationsThroughout this I will be developing several novel processes such as how to engineer DNA and RNA structures so that they are compatible in prokaryotes which will not just be relevant to in vivo data storage but can have applications in the medical therapeutic industry to name but one.