课题基金 / 基金详情

COMPUTATIONAL METHODS IN GENETIC EPIDEMIOLOGY

COMPUTATIONAL METHODS IN GENETIC EPIDEMIOLOGY
遗传流行病学的计算方法
批准号:
6628874
负责人:
Duncan C. Thomas
金额:
$50.31万
依托单位国家:
美国
项目类别:
财政年份:
2000
资助国家:
美国
项目状态:
已结题
起止时间:
2000-02-01 至 2004-08-31

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中文摘要
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英文摘要
In this grant, we propose to focus further work on computational problems in gene mapping studies, with particular emphasis on finding genes for complex traits combining linkage and linkage disequilibrium information. Combining research forces at both the University of Southern California (USC) and the Fred Hutchinson Cancer Research Center (FHCRC), we propose to explore the following approaches for joint linkage and linkage disequilibrium analysis: Maximum likelihood methods using both empirical models for disequilibrium and population genetics models for isolated and admixed populations. Efficient Estimating Equations (EEE) methods for semi-parametric analysis MCMC methods for larger pedigrees than are currently feasible.
期刊论文(19)
专著(0)
科研奖励(0)
会议论文
A statistically driven approach for image segmentation and signal extraction in cDNA microarrays.
一种统计驱动的 cDNA 微阵列图像分割和信号提取方法。
DOI: 10.1089/cmb.2004.11.695
发表时间: 2004
期刊: Journal of computational biology : a journal of computational molecular cell biology.
影响因子: --
作者: [Bergemann,TL, Laws,RJ, Quiaoit,F, Zhao,LP]
通讯作者: Zhao,LP
DOI: 10.1186/1479-7364-2-2-144
发表时间: 2005-06
期刊: Human genomics
影响因子: 4.5
作者: [Stram DO]
通讯作者: Stram DO
Application of Bayesian spatial statistical methods to analysis of haplotypes effects and gene mapping.
应用贝叶斯空间统计方法分析单倍型效应和基因作图。
DOI: 10.1002/gepi.10251
发表时间: 2003
期刊: Genetic epidemiology.
影响因子: --
作者: [Molitor,John, Marjoram,Paul, Thomas,Duncan]
通讯作者: Thomas,Duncan
SignalViewer: analyzing microarray images.
SignalViewer:分析微阵列图像。
DOI: 10.1093/bioinformatics/btg208
发表时间: 2003
期刊: Bioinformatics (Oxford, England)
影响因子: --
作者: [Laws,RJ, Bergemann,TL, Quiaoit,F, Zhao,LP]
通讯作者: Zhao,LP
6
    Exogenous and Genetic Determinants of the Internal Environment
    • 批准号:
      9072859
    • 项目类别:
    • 资助金额:
      $26.88万
    • 财政年份:
      2016
    • 负责人:
      Duncan C. Thomas
    • 依托单位:
    Statistical Methods for Epigenetic Mediation of Exposure-response Relations
    • 批准号:
      8600681
    • 项目类别:
    • 资助金额:
      $16.26万
    • 财政年份:
      2012
    • 负责人:
      Duncan C. Thomas
    • 依托单位:
    Statistical Methods for Epigenetic Mediation of Exposure-response Relations
    • 批准号:
      8219246
    • 项目类别:
    • 资助金额:
      $16.35万
    • 财政年份:
      2012
    • 负责人:
      Duncan C. Thomas
    • 依托单位:
    Statistical Methods for Epigenetic Mediation of Exposure-response Relations
    • 批准号:
      8416895
    • 项目类别:
    • 资助金额:
      $16.07万
    • 财政年份:
      2012
    • 负责人:
      Duncan C. Thomas
    • 依托单位:
    海外基金