MODULATION OF LOCAL BONE TISSUE MATERIAL PROPERTIES
局部骨组织材料特性的调节
基本信息
- 批准号:6632753
- 负责人:
- 金额:$ 20.19万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-08-01 至 2005-05-31
- 项目状态:已结题
- 来源:
- 关键词:biomechanics bone density bone metabolism cell population study disease /disorder model estrogens female joint stiffness longitudinal animal study minerals morphometry muscle strength normal ossification osteocytes osteoporosis ovariectomy photon absorptiometry physical property postmenopause radiotracer sheep tensile strength tetracyclines tissue /cell culture
项目摘要
DESCRIPTION (provided by applicant): Compact bone mineral density is
distributed non-uniformly within the normal bone structure. This is reflected
in local variation in mechanical properties (strength and stiffness) that we
believe helps to limit bending to those planes where muscles and ligaments have
maximal mechanical influence. Challenges to normal bone mineral metabolism may
affect this material distribution, and have structural effects disproportionate
to the overall mineral loss. For instance, in postmenopausal osteoporosis,
there is increased turnover of bone, and a generalized loss of bone mass, but
this fully explains neither the strong association with fracture incidence, nor
the substantial overlap between unaffected and fracture patients in most
clinical screening measures of bone quality. Given the pre-existing material
heterogeneity, any change in material properties, be it random, uniform, or
systematic, is likely to have significant effects on the mechanical behavior of
the structure. Therefore, therapeutic interventions designed to simply affect
an overall increase in bone mass without considering regional mechanical
property variation may be ineffective in preventing fracture.
In compact bone, an increase in bone turnover may be seen as a branching
problem in angiogenesis: new osteons, and their blood vessels, must arise from
pre-existing osteons and blood vessels. If estrogen depletion were associated
with a global increase in vascular and osteonal branching, the major early
effects of remodeling would be seen in regions with high concentrations of
pre-existing osteons. Such a scenario would produce an immediate systematic
change in regional bone density that would be related not to original density,
but to pre-existing remodeling patterns. Furthermore, we hypothesize that the
new bone that is laid down in the estrogen-depleted condition is less densely
populated by osteocytes than in the intact animal. If changes in osteocyte
density were associated with alterations in the final mineralization of new
bone, a more permanent change in the distribution of material properties would
then ensue.
We will test these hypotheses using the ovariectomized-sheep model of estrogen
depletion. The radius/ulna will be tested for structural damping, stiffness,
and strength before sectioning into regions for materials testing and
histology. Remodeling activity will be quantified by dynamic and static
histomorphometry, and by analysis of osteonal density patterns. Finally, local
osteocyte population densities will be determined and compared with osteonal
mineral measurements, and with mineral-independent measurements of local tissue
age. In this way, we will address the issue of compact bone material
heterogeneity in postmenopausal osteoporosis at the structural, materials, cell
population, and biochemical levels.
描述(由申请人提供):骨密度紧凑
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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CLIFFORD MICHAEL LES其他文献
CLIFFORD MICHAEL LES的其他文献
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{{ truncateString('CLIFFORD MICHAEL LES', 18)}}的其他基金
Degradation and Recovery of Bone: OVX and Treatment
骨的退化和恢复:OVX 和治疗
- 批准号:
7387437 - 财政年份:2005
- 资助金额:
$ 20.19万 - 项目类别:
Degradation and Recovery of Bone: OVX and Treatment
骨的退化和恢复:OVX 和治疗
- 批准号:
6924988 - 财政年份:2005
- 资助金额:
$ 20.19万 - 项目类别:
Degradation and Recovery of Bone: OVX and Treatment
骨的退化和恢复:OVX 和治疗
- 批准号:
7050616 - 财政年份:2005
- 资助金额:
$ 20.19万 - 项目类别:
Degradation and Recovery of Bone: OVX and Treatment
骨的退化和恢复:OVX 和治疗
- 批准号:
7197332 - 财政年份:2005
- 资助金额:
$ 20.19万 - 项目类别:
Degradation and Recovery of Bone: OVX and Treatment
骨的退化和恢复:OVX 和治疗
- 批准号:
7600520 - 财政年份:2005
- 资助金额:
$ 20.19万 - 项目类别:
MODULATION OF LOCAL BONE TISSUE MATERIAL PROPERTIES
局部骨组织材料特性的调节
- 批准号:
6512163 - 财政年份:2001
- 资助金额:
$ 20.19万 - 项目类别:
MODULATION OF LOCAL BONE TISSUE MATERIAL PROPERTIES
局部骨组织材料特性的调节
- 批准号:
6769328 - 财政年份:2001
- 资助金额:
$ 20.19万 - 项目类别:
MODULATION OF LOCAL BONE TISSUE MATERIAL PROPERTIES
局部骨组织材料特性的调节
- 批准号:
6383216 - 财政年份:2001
- 资助金额:
$ 20.19万 - 项目类别:
MATERIAL PROPERTIES AND REMODELING IN THE METACARPUS
掌骨的材料特性和重塑
- 批准号:
2077977 - 财政年份:1994
- 资助金额:
$ 20.19万 - 项目类别:
MATERIAL PROPERTIES AND REMODELING IN THE METACARPUS
掌骨的材料特性和重塑
- 批准号:
2077976 - 财政年份:1993
- 资助金额:
$ 20.19万 - 项目类别:
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